[HTML][HTML] ACE2: the major cell entry receptor for SARS-CoV-2

F Scialo, A Daniele, F Amato, L Pastore, MG Matera… - Lung, 2020 - Springer
Despite the unprecedented effort of the scientific community, the novel SARS-CoV-2 virus
has infected more than 46 million people worldwide, killing over one million two hundred …

[HTML][HTML] Sex differences in severity and mortality from COVID-19: are males more vulnerable?

A Pradhan, PE Olsson - Biology of sex Differences, 2020 - Springer
Abstract Coronavirus disease 2019 (COVID-19) has shown high infection and mortality rates
all over the world, and despite the global efforts, there is so far no specific therapy available …

Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin–angiotensin–aldosterone inhibitors

IE Sama, A Ravera, BT Santema… - European heart …, 2020 - academic.oup.com
Aims The current pandemic coronavirus SARS-CoV-2 infects a wide age group but
predominantly elderly individuals, especially men and those with cardiovascular disease …

[HTML][HTML] Angiotensin-converting enzyme 2—at the heart of the COVID-19 pandemic

GY Oudit, K Wang, A Viveiros, MJ Kellner… - Cell, 2023 - cell.com
ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the
COVID-19 pandemic, it has become one of the most therapeutically targeted human …

Role of the ACE2/angiotensin 1–7 axis of the renin–angiotensin system in heart failure

VB Patel, JC Zhong, MB Grant, GY Oudit - Circulation research, 2016 - Am Heart Assoc
Heart failure (HF) remains the most common cause of death and disability, and a major
economic burden, in industrialized nations. Physiological, pharmacological, and clinical …

Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration

CP Sodhi, C Wohlford-Lenane… - … of Physiology-Lung …, 2018 - journals.physiology.org
Angiotensin-converting enzyme 2 (ACE2) is a terminal carboxypeptidase with important
functions in the renin-angiotensin system and plays a critical role in inflammatory lung …

[HTML][HTML] ACE2 in the era of SARS-CoV-2: controversies and novel perspectives

F Saponaro, G Rutigliano, S Sestito… - Frontiers in Molecular …, 2020 - frontiersin.org
Angiotensin-converting enzyme 2 (ACE2) is related to ACE but turned out to counteract
several pathophysiological actions of ACE. ACE2 exerts antihypertensive and …

[HTML][HTML] MicroRNA mimics or inhibitors as antiviral therapeutic approaches against COVID-19

C Hum, J Loiselle, N Ahmed, TA Shaw, C Toudic… - Drugs, 2021 - Springer
Coronaviruses, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
responsible for the coronavirus disease 2019 (COVID-19) pandemic, present a significant …

[HTML][HTML] Kidney and lung ACE2 expression after an ACE inhibitor or an Ang II receptor blocker: implications for COVID-19

J Wysocki, E Lores, M Ye, MJ Soler… - Journal of the American …, 2020 - journals.lww.com
After the recognition early in 2020 that angiotensin-converting enzyme 2 (ACE2) is the main
receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 1 concerns …

Epigenetic regulation of ACE2, the receptor of the SARS-CoV-2 virus1

TH Beacon, GP Delcuve, JR Davie - Genome, 2021 - cdnsciencepub.com
The angiotensin-converting enzyme 2 (ACE2) is the receptor for the three coronaviruses
HCoV-NL63, SARS-CoV, and SARS-CoV-2. ACE2 is involved in the regulation of the renin …