Over the past two decades a growing body of evidence has demonstrated an important role
of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease …

Claudins are major integral membrane proteins of tight junctions. Altered expression of
several claudin proteins, in particular claudin-1,-3,-4 and-7, has been linked to the …

Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is
overexpressed in many epithelial malignancies and correlates with cancer progression …

Tight junctions (TJ) are multi-protein complexes located at the apicalmost tip of the lateral
membrane in polarised epithelial and endothelial cells. Their principal function is in …

Increasing evidence has linked claudins to signal transduction and tumorigenesis. The
expression of claudins is frequently dysregulated in the context of neoplastic transformation …

Tight junctions (TJs) are an important component of cell connectivity; they maintain cell
polarity, permeability and adhesion, and participate in the regulation of cell proliferation and …

Claudins are four-transmembrane proteins, which were found in tight junctions. They
maintain cell barriers and regulate cell differentiation and proliferation. They are involved in …

Clostridium perfringens enterotoxin (CPE) is a three-domain polypeptide, which binds to
Claudin-3 and Claudin-4 with high affinity. Because these receptors are highly differentially …

Abstract Background Claudin-4 (CLDN4), a tight junction protein, is overexpressed in
several types of cancer, and is considered a biomarker for cancer-targeted treatment …

Previous studies have shown that the expression of claudin-4 is upregulated in breast
cancer. The aim of the present study was to investigate the role and the regulation of claudin …