Background Despite the increasing knowledge of the etiology of neuropathic pain, this type
of chronic pain is resistant to available analgesics in approximately 50% of patients and …

Metformin (biguanide) is a drug widely used for the treatment of type 2 diabetes. This drug
has been used for 60 years as a highly effective antihyperglycemic agent. The search for the …

Extrasynaptic α5‐subunit containing GABAA (α5‐GABAA) receptors participate in chronic
pain. Previously, we reported a sex difference in the action of α5‐GABAA receptors in …

This study investigated the effects of syringic acid (SA) on renal, cardiac, hepatic, and
neuronal diabetic complications in streptozotocin-induced neonatal (nSTZ) diabetic rats …

Satellite glial cells (SGCs) surrounding the neuronal somas in peripheral sensory ganglia
are sensitive to neuronal stressors, which induce their reactive state. It is believed that such …

Background and Purpose New remedies are required for the treatment of diabetic
neuropathic pain (DNP) due to insufficient efficacy of available therapies. Here, we used …

The purpose of this study was to investigate the mechanism of antiallodynic effect of
tizanidine in neuropathic rats. Spinal nerve ligation reduced withdrawal threshold which was …

Astrocytes are a population of central nervous system (CNS) cells with distinctive
morphological and functional characteristics that differ within specific areas of the brain and …

Background: Cilostazol is an antiplatelet agent with vasodilating, endothelial function
restoration, and anti-inflammatory effects. This study aims to investigate the efficacy of oral …

Peripheral neuropathy is one of the main complications of diabetes. The pathogenesis of
this affectation is not completely understood. Several studies refer to hyperglycemia as the …