Cannabinoid formulations and delivery systems: Current and future options to treat pain

B Stella, F Baratta, C Della Pepa, S Arpicco, D Gastaldi… - Drugs, 2021 - Springer
The field of Cannabis sativa L. research for medical purposes has been rapidly advancing in
recent decades and a growing body of evidence suggests that phytocannabinoids are …

Conversion technologies for valorization of hemp lignocellulosic biomass for potential biorefinery applications

M Tripathi, M Sharma, S Bala, J Connell… - Separation and …, 2023 - Elsevier
Fossil fuel supplies are becoming scarce as a result of the growing world's population. The
increasing use of fossil fuels also pose a threat to ecosystem. Renewable energy sources …

[HTML][HTML] The emerging role of quercetin in the treatment of chronic pain

C Liu, DQ Liu, YK Tian, W Mei, XB Tian… - Current …, 2022 - ncbi.nlm.nih.gov
Despite much research efforts being devoted to designing alternative pharmacological
interventions, chronic pain remains to be an unresolved clinical problem. Quercetin, a …

A sensitive ultrahigh-performance liquid chromatography/tandem mass spectrometry method for the simultaneous analysis of phytocannabinoids and …

F Ahmed, A Torrens, SV Mahler… - Cannabis and …, 2024 - liebertpub.com
Introduction: Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are major chemical
constituents of cannabis, which may interact either directly or indirectly with the …

NAAA-regulated lipid signaling in monocytes controls the induction of hyperalgesic priming in mice

Y Fotio, A Mabou Tagne, E Squire, H Lee… - Nature …, 2024 - nature.com
Circulating monocytes participate in pain chronification but the molecular events that cause
their deployment are unclear. Using a mouse model of hyperalgesic priming (HP), we show …

Δ9-Tetrahydrocannabinol alleviates hyperalgesia in a humanized mouse model of sickle cell disease

AM Tagne, Y Fotio, K Gupta… - … of Pharmacology and …, 2024 - jpet.aspetjournals.org
People with sickle cell disease (SCD) often experience chronic pain as well as
unpredictable episodes of acute pain, which significantly affects their quality of life and life …

Synergistic antinociceptive effects of concomitant NAAA and peripheral FAAH inhibition

AM Tagne, Y Fotio, PS Uppal, D Piomelli - Experimental Neurology, 2022 - Elsevier
The intracellular lipid amidases, fatty acid amide hydrolase (FAAH) and N-acylethanolamine
acid amidase (NAAA), terminate the actions of anandamide and palmitoylethanolamide …

Unraveling brain palmitic acid: Origin, levels and metabolic fate

ME Smith, RP Bazinet - Progress in Lipid Research, 2024 - Elsevier
In the human brain, palmitic acid (16: 0; PAM) comprises nearly half of total brain saturates
and has been identified as the third most abundant fatty acid overall. Brain PAM supports the …

Cannabis Extract Has a Positive–Immunostimulating Effect through Proteolytic System and Metabolic Compounds of Honey Bee (Apis mellifera) Workers

P Skowronek, Ł Wójcik, A Strachecka - Animals, 2021 - mdpi.com
Simple Summary The aim of our study was to test the immunostimulating effect of a diet with
hemp extract on the resistance of the honey bee (Apis mellifera). The experiment compared …

Chronic pain in dogs and cats: Is there place for dietary intervention with micro-palmitoylethanolamide?

G Della Rocca, D Gamba - Animals, 2021 - mdpi.com
Simple Summary Chronic pain is being increasingly recognized and addressed in small
animal practice. The recent recognition that inability to communicate does not negate the …