The human stress response has evolved to maintain homeostasis under conditions of real or
perceived stress. This objective is achieved through autoregulatory neural and hormonal …

Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …

The mammalian circadian clock has evolved as an adaptation to the 24-h light/darkness
cycle on earth. Maintaining cellular activities in synchrony with the activities of the organism …

Abstract ELONGATED HYPOCOTYL5 (HY5), a member of the bZIP transcription factor
family, inhibits hypocotyl growth and lateral root development, and promotes pigment …

Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

The circadian timing system synchronizes cellular function by coordinating rhythmic
transcription via a transcription-translational feedback loop. How the circadian system …

Daily rhythms in physiology significantly modulate drug pharmacokinetics and
pharmacodynamics according to the time-of-day, a finding that has led to the concept of …

Chrononutrition is an emerging discipline that builds on the intimate relation between
endogenous circadian (24-h) rhythms and metabolism. Circadian regulation of metabolic …

It has been nearly 300 years since the first scientific demonstration of a self-sustaining
circadian clock in plants. It has become clear that plants are richly rhythmic, and many …

The cell cycle and the circadian clock operate as biological oscillators whose timed
functions are tightly regulated. Accumulating evidence illustrates the presence of molecular …