Research conducted in the past 15 years has yielded crucial insights that are reshaping our
understanding of the systems physiology of branched-chain amino acid (BCAA) metabolism …

The heart utilizes large amounts of fatty acids as energy providing substrates. The
physiological balance of lipid uptake and oxidation prevents accumulation of excess lipids …

Background—Although metabolic reprogramming is critical in the pathogenesis of heart
failure, studies to date have focused principally on fatty acid and glucose metabolism …

Skeletal muscle fitness and plasticity is an important determinant of human health and
disease. Mitochondria are essential for maintaining skeletal muscle energy homeostasis by …

1704 Circulation Research May 27, 2016 of epigenetic mechanisms contributing to
macrovascular disease in diabetes. The authors highlight the recent identification of …

Background Branched chain amino acids (BCAA) can impair insulin signaling, and cardiac
insulin resistance can occur in the failing heart. We, therefore, determined if cardiac BCAA …

The mitochondrion is a complex organelle that serves essential roles in energy transduction,
ATP production, and a myriad of cellular signaling events. A finely tuned regulatory network …

Background Whole genome duplication (WGD) events have played a major role in
eukaryotic genome evolution, but the consequence of these extreme events in adaptive …

The heart requires fatty acids to maintain its activity. Various mechanisms regulate
myocardial fatty acid metabolism, such as energy production using fatty acids as fuel, for …

Nonischemic cardiomyopathy (NICM) resulting from long-standing hypertension, valvular
disease, and genetic mutations is a major cause of heart failure worldwide. Recent …