Biotechnological interventions for harnessing podophyllotoxin from plant and fungal species: current status, challenges, and opportunities for its commercialization
Podophyllotoxin is an aryltetralin lignan synthesized in several plant species, which is used
in chemotherapies for cancers and tumor treatment. More potent semisynthetic derivatives of …
in chemotherapies for cancers and tumor treatment. More potent semisynthetic derivatives of …
Transcriptome repository of North-Western Himalayan endangered medicinal herbs: a paramount approach illuminating molecular perspective of phytoactive …
Medicinal plants of the North-Western Himalayan region are known for their unprecedented
biodiversity and valuable secondary metabolites that are unique to this dynamic geo-climatic …
biodiversity and valuable secondary metabolites that are unique to this dynamic geo-climatic …
Light-Induced Flavonoid Biosynthesis in Sinopodophyllum hexandrum with High-Altitude Adaptation
Q Zhao, M Dong, M Li, L Jin, PW Paré - Plants, 2023 - mdpi.com
Sinopodophyllum hexandrum is a perennial alpine herb producing the anti-cancer
metabolite podophyllotoxin (PPT). Although the adaptation of S. hexandrum to high altitudes …
metabolite podophyllotoxin (PPT). Although the adaptation of S. hexandrum to high altitudes …
Effect of UV‐B radiation on growth, flavonoid and podophyllotoxin accumulation, and related gene expression in Sinopodophyllum hexandrum
M Lv, HY Su, ML Li, DL Yang, RY Yao, MF Li… - Plant …, 2021 - Wiley Online Library
Sinopodophyllum hexandrum is an alpine medicinal plant that produces the anticancer
compound podophyllotoxin (PPT). Although a positive relationship between PPT content …
compound podophyllotoxin (PPT). Although a positive relationship between PPT content …
Stress-Responsive cis-Regulatory Elements Underline Podophyllotoxin Biosynthesis and Better Performance of Sinopodophyllum hexandrum Under Water Deficit …
Sinopodophyllum hexandrum is an endangered medicinal herb known for its bioactive
lignan podophyllotoxin (PTOX), which is used for the preparation of anticancer drugs. In its …
lignan podophyllotoxin (PTOX), which is used for the preparation of anticancer drugs. In its …
Expression analysis of biosynthetic pathway genes vis-à-vis podophyllotoxin content in Podophyllum hexandrum Royle
Podophyllum hexandrum Royle is known for its vast medicinal properties, particularly
anticancer. It contains higher amount of podophyllotoxin (4.3%), compared to Podophyllum …
anticancer. It contains higher amount of podophyllotoxin (4.3%), compared to Podophyllum …
Comparison of the Mitochondrial Genomes and Steady State Transcriptomes of Two Strains of the Trypanosomatid Parasite, Leishmania tarentolae
L Simpson, SM Douglass, JA Lake… - PLoS neglected …, 2015 - journals.plos.org
U-insertion/deletion RNA editing is a post-transcriptional mitochondrial RNA modification
phenomenon required for viability of trypanosomatid parasites. Small guide RNAs encoded …
phenomenon required for viability of trypanosomatid parasites. Small guide RNAs encoded …
De novo transcriptome provides insights into the growth behaviour and resveratrol and trans-stilbenes biosynthesis in Dactylorhiza hatagirea - An endangered …
This is the first report on de novo transcriptome of Dactylorhiza hatagirea, a critically-
endangered, terrestrial orchid of alpine Himalayas. The plant is acclaimed for medicinal …
endangered, terrestrial orchid of alpine Himalayas. The plant is acclaimed for medicinal …
Synthesis of (−)−deoxypodophyllotoxin and (−)−epipodophyllotoxin via a multi-enzyme cascade in E. coli
D Decembrino, A Raffaele, R Knöfel, M Girhard… - Microbial Cell …, 2021 - Springer
Abstract Background The aryltetralin lignan (−)− podophyllotoxin is a potent antiviral and
anti-neoplastic compound that is mainly found in Podophyllum plant species. Over the years …
anti-neoplastic compound that is mainly found in Podophyllum plant species. Over the years …
High-elevation cultivation increases anti-cancer podophyllotoxin accumulation in Podophyllum hexandrum
M Li, L Ge, T Kang, P Sun, H Xing, D Yang… - Industrial Crops and …, 2018 - Elsevier
Podophyllum hexandrum, a perennial alpine herb produces the anti-cancer metabolite
podophyllotoxin (PPT) that is in large part responsible for the plant's endangered species …
podophyllotoxin (PPT) that is in large part responsible for the plant's endangered species …