[HTML][HTML] The'middle-aging'brain
Middle age has historically been an understudied period of life compared to older age, when
cognitive and brain health decline are most pronounced, but the scope for intervention may …
cognitive and brain health decline are most pronounced, but the scope for intervention may …
Neurogenesis in primates versus rodents and the value of non-human primate models
R Zhang, H Quan, Y Wang, F Luo - National Science Review, 2023 - academic.oup.com
Neurogenesis, the process of generating neurons from neural stem cells, occurs during both
embryonic and adult stages, with each stage possessing distinct characteristics. Dysfunction …
embryonic and adult stages, with each stage possessing distinct characteristics. Dysfunction …
[HTML][HTML] Automatic cell-type harmonization and integration across Human Cell Atlas datasets
Harmonizing cell types across the single-cell community and assembling them into a
common framework is central to building a standardized Human Cell Atlas. Here, we present …
common framework is central to building a standardized Human Cell Atlas. Here, we present …
Prolonged fixation and post-mortem delay impede the study of adult neurogenesis in mice
M Gallardo-Caballero, CB Rodríguez-Moreno… - Communications …, 2023 - nature.com
Adult hippocampal neurogenesis (AHN) gives rise to new neurons throughout life. This
phenomenon takes place in more than 120 mammalian species, including humans, yet its …
phenomenon takes place in more than 120 mammalian species, including humans, yet its …
Electroconvulsive therapy is associated with increased immunoreactivity of neuroplasticity markers in the hippocampus of depressed patients
D Loef, I Tendolkar, PFP van Eijndhoven… - Translational …, 2023 - nature.com
Electroconvulsive therapy (ECT) is an effective therapy for depression, but its cellular effects
on the human brain remain elusive. In rodents, electroconvulsive shocks increase …
on the human brain remain elusive. In rodents, electroconvulsive shocks increase …
[HTML][HTML] Altered in vivo early neurogenesis traits in patients with depression: Evidence from neuron-derived extracellular vesicles and electroconvulsive therapy
Background The neurogenesis hypothesis is a promising candidate etiologic hypothesis for
depression, and it is associated with electroconvulsive therapy (ECT). However, human in …
depression, and it is associated with electroconvulsive therapy (ECT). However, human in …
A brain cell atlas integrating single-cell transcriptomes across human brain regions
X Chen, Y Huang, L Huang, Z Huang, ZZ Hao, L Xu… - Nature Medicine, 2024 - nature.com
While single-cell technologies have greatly advanced our comprehension of human brain
cell types and functions, studies including large numbers of donors and multiple brain …
cell types and functions, studies including large numbers of donors and multiple brain …
Transcriptional dynamics orchestrating the development and integration of neurons born in the adult hippocampus
NB Rasetto, D Giacomini, AA Berardino… - Science …, 2024 - science.org
The adult hippocampus generates new granule cells (aGCs) with functional capabilities that
convey unique forms of plasticity to the preexisting circuits. While early differentiation of adult …
convey unique forms of plasticity to the preexisting circuits. While early differentiation of adult …
The concept of resilience to Alzheimer's Disease: current definitions and cellular and molecular mechanisms
LE de Vries, I Huitinga, HW Kessels, DF Swaab… - Molecular …, 2024 - Springer
Some individuals are able to maintain their cognitive abilities despite the presence of
significant Alzheimer's Disease (AD) neuropathological changes. This discrepancy between …
significant Alzheimer's Disease (AD) neuropathological changes. This discrepancy between …
[HTML][HTML] The missing hallmark of health: psychosocial adaptation
C López-Otín, G Kroemer - Cell Stress, 2024 - ncbi.nlm.nih.gov
The eight biological hallmarks of health that we initially postulated (Cell. 2021 Jan 7; 184 (1):
33-63) include features of spatial compartmentalization (integrity of barriers, containment of …
33-63) include features of spatial compartmentalization (integrity of barriers, containment of …