Middle age has historically been an understudied period of life compared to older age, when
cognitive and brain health decline are most pronounced, but the scope for intervention may …

Neurogenesis, the process of generating neurons from neural stem cells, occurs during both
embryonic and adult stages, with each stage possessing distinct characteristics. Dysfunction …

Harmonizing cell types across the single-cell community and assembling them into a
common framework is central to building a standardized Human Cell Atlas. Here, we present …

Adult hippocampal neurogenesis (AHN) gives rise to new neurons throughout life. This
phenomenon takes place in more than 120 mammalian species, including humans, yet its …

Electroconvulsive therapy (ECT) is an effective therapy for depression, but its cellular effects
on the human brain remain elusive. In rodents, electroconvulsive shocks increase …

Background The neurogenesis hypothesis is a promising candidate etiologic hypothesis for
depression, and it is associated with electroconvulsive therapy (ECT). However, human in …

While single-cell technologies have greatly advanced our comprehension of human brain
cell types and functions, studies including large numbers of donors and multiple brain …

The adult hippocampus generates new granule cells (aGCs) with functional capabilities that
convey unique forms of plasticity to the preexisting circuits. While early differentiation of adult …

Some individuals are able to maintain their cognitive abilities despite the presence of
significant Alzheimer's Disease (AD) neuropathological changes. This discrepancy between …

The eight biological hallmarks of health that we initially postulated (Cell. 2021 Jan 7; 184 (1):
33-63) include features of spatial compartmentalization (integrity of barriers, containment of …