Energy homeostasis during fasting or prolonged exercise depends on mitochondrial fatty
acid oxidation (FAO). This pathway is crucial in many tissues with high energy demand and …

Both heart failure with reduced ejection fraction (HFrEF) and with preserved ejection fraction
(HFpEF) are associated with high morbidity and mortality. Although many established …

Chronic lymphocytic leukemia (CLL) is a hematological malignancy with high metabolic
heterogeneity. N6‐methyladenosine (m6A) modification plays an important role in …

Background The presence and extent of left ventricular hypertrophy (LVH) is a major
determinant of symptoms in patients with hypertrophic cardiomyopathy (HCM). There is …

Simple Summary Cancer cells frequently have an altered metabolism to support their
increased proliferative and invasive activity. Perhexiline, a drug used to treat some …

HSP90 is a molecular chaperone required for stabilization and activation of hundreds of
client proteins, including many known oncoproteins. AUY922 (luminespib), a new …

Aims Heart failure in adults is characterized by reduction of long‐chain fatty acid oxidation in
favour of carbohydrate metabolism. This adaptive phenomenon becomes maladaptive …

Approaches to the pharmacotherapy of angina pectoris have previously centred on the
concept that a transient imbalance between myocardial oxygen “demand” and supply within …

Hysterectomy is one of the most commonly performed gynecologic surgeries, mainly for
uterine myomas, abnormal uterine bleeding, and prolapses. It can be performed through …

Introduction: Angina pectoris, or symptomatic myocardial ischaemia, reflects an impairment
of coronary blood flow, and usually a deficiency of available myocardial energetics …