Microfluidic chips: recent advances, critical strategies in design, applications and future perspectives

P Pattanayak, SK Singh, M Gulati, S Vishwas… - Microfluidics and …, 2021 - Springer
Microfluidic chip technology is an emerging tool in the field of biomedical application.
Microfluidic chip includes a set of groves or microchannels that are engraved on different …

Small but perfectly formed? Successes, challenges, and opportunities for microfluidics in the chemical and biological sciences

DT Chiu, AJ Demello, D Di Carlo, PS Doyle, C Hansen… - Chem, 2017 - cell.com
Microfluidic systems are pervasive in many areas of experimental science, but what are the
real advantages of this technology? We describe some of the features and properties that …

NeuroPAL: a multicolor atlas for whole-brain neuronal identification in C. elegans

E Yemini, A Lin, A Nejatbakhsh, E Varol, R Sun… - Cell, 2021 - cell.com
Comprehensively resolving neuronal identities in whole-brain images is a major challenge.
We achieve this in C. elegans by engineering a multicolor transgene called NeuroPAL (a …

Brain-on-a-chip: Recent advances in design and techniques for microfluidic models of the brain in health and disease

L Amirifar, A Shamloo, R Nasiri, NR de Barros… - Biomaterials, 2022 - Elsevier
Recent advances in biomaterials, microfabrication, microfluidics, and cell biology have led to
the development of organ-on-a-chip devices that can reproduce key functions of various …

Sensitive red protein calcium indicators for imaging neural activity

H Dana, B Mohar, Y Sun, S Narayan, A Gordus… - elife, 2016 - elifesciences.org
Genetically encoded calcium indicators (GECIs) allow measurement of activity in large
populations of neurons and in small neuronal compartments, over times of milliseconds to …

On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves

X Ding, SCS Lin, B Kiraly, H Yue, S Li… - Proceedings of the …, 2012 - National Acad Sciences
Techniques that can dexterously manipulate single particles, cells, and organisms are
invaluable for many applications in biology, chemistry, engineering, and physics. Here, we …

Neuronal small RNAs control behavior transgenerationally

R Posner, IA Toker, O Antonova, E Star, S Anava… - Cell, 2019 - cell.com
It is unknown whether the activity of the nervous system can be inherited. In Caenorhabditis
elegans nematodes, parental responses can transmit heritable small RNAs that regulate …

Brain-wide 3D imaging of neuronal activity in Caenorhabditis elegans with sculpted light

T Schrödel, R Prevedel, K Aumayr, M Zimmer… - Nature methods, 2013 - nature.com
Recent efforts in neuroscience research have been aimed at obtaining detailed anatomical
neuronal wiring maps as well as information on how neurons in these networks engage in …

The rich club of the C. elegans neuronal connectome

EK Towlson, PE Vértes, SE Ahnert… - Journal of …, 2013 - Soc Neuroscience
There is increasing interest in topological analysis of brain networks as complex systems,
with researchers often using neuroimaging to represent the large-scale organization of …

Dissecting a circuit for olfactory behaviour in Caenorhabditis elegans

SH Chalasani, N Chronis, M Tsunozaki, JM Gray… - Nature, 2007 - nature.com
Although many properties of the nervous system are shared among animals and systems, it
is not known whether different neuronal circuits use common strategies to guide behaviour …