Migraine is an episodic neurovascular disorder that is clinically divided into two main
subtypes that are based on the absence or presence of an aura: migraine without aura (MO) …

Although family and twin studies show that there is a genetic component to migraine, no
genes predisposing to common forms of the disorder have been identified. The most …

Insight into the molecular mechanisms involved in primary headaches is important to identify
drug targets for improving treatment of patients, but essentially lacking. Genetic research is …

Migraine is a neurological disorder that affects the central nervous system causing painful
attacks of headache. A genetic vulnerability and exposure to environmental triggers can …

Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura and transient
hemiplegia. FHM mutations are known in three genes, the CACNA1A (FHM1) gene, the …

Recurrent episodes of transient focal neurologic symptoms, known as aura, occur in
association with migraine headache in about 11.9 million people in the United States. At …

The commonly used" end diagnosis" phenotype that is adopted in linkage and association
studies of complex traits is likely to represent an oversimplified model of the genetic …

Objective: To investigate the molecular genetic basis of cluster headache (CH), using a
genome-wide scan and candidate gene strategy. Methods: Northern European CH families …

It is often debated whether migraine with aura (MA) and migraine without aura (MO) are
etiologically distinct disorders. A previous study using latent class analysis (LCA) in …

Migraine is a common neurological disorder with a strong genetic basis. However, the
complex nature of the disorder has meant that few genes or susceptibility loci have been …