Inflammation is a hallmark and potent driver of pathological vascular remodelling in
atherosclerosis. However, current anti-inflammatory therapeutic strategies have shown …

Intracranial aneurysm subarachnoid hemorrhage (SAH) is a cerebrovascular disorder
associated with high overall mortality. Currently, the underlying mechanisms of pathological …

Background In 2014, germline signal transducer and activator of transcription (STAT) 3 gain-
of-function (GOF) mutations were first described to cause a novel multisystem disease of …

Atherosclerosis is the main pathological basis of ischemic cardiovascular and
cerebrovascular diseases and has attracted more attention in recent years. Multiple studies …

Several studies have processed conceivable evidence for the vital role of Signal Transducer
and Activator of Transcription 3 (STAT3) in cancer transformation and carcinogenesis …

Diabetes mellitus (DM) is a strong risk factor for the development of cardiovascular diseases
such as coronary heart disease, cerebrovascular disease, and peripheral arterial disease …

Metastasis is the primary cause of cancer-related mortality. Tumor cell interactions with cells
of the vessel wall are decisive and potentially rate-limiting for metastasis. The molecular …

Rheumatoid arthritis (RA) is classified as an inflammatory, chronic autoimmune and
disabling disease based on the intricate interplay between environmental and genetic …

Inflammatory mediators in tumor microenvironment influence cancer occurrence, growth and
metastasis through complex signaling networks. Excessive inflammation is closely …

Angiogenesis is the development of new blood vessels, which is required for tumor growth
and metastasis. Signal transducer and activator of transcription factor 3 (STAT3) is a …