Brain and peripheral atypical inflammatory mediators potentiate neuroinflammation and neurodegeneration

D Kempuraj, R Thangavel, GP Selvakumar… - Frontiers in cellular …, 2017 - frontiersin.org
Neuroinflammatory response is primarily a protective mechanism in the brain. However,
excessive and chronic inflammatory responses can lead to deleterious effects involving …

Incretin-based drugs as potential therapy for neurodegenerative diseases: current status and perspectives

F Ferrari, A Moretti, RF Villa - Pharmacology & therapeutics, 2022 - Elsevier
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most frequent
neurodegenerative disorders. Despite their pathophysiological and clinical differences, they …

Neprilysin inhibitors and risk of Alzheimer's disease: A future perspective

NH Ali, HM Al‐Kuraishy, AI Al‐Gareeb… - Journal of cellular …, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a heterogeneous neurodegenerative disease with multifaceted
neuropathological disorders. AD is characterized by intracellular accumulation of …

Neuropeptides exert neuroprotective effects in Alzheimer's disease

XY Chen, YF Du, L Chen - Frontiers in Molecular Neuroscience, 2019 - frontiersin.org
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by
cognitive deficits and neuronal loss. Deposition of beta-amyloid peptide (Aβ) causes …

The therapeutic potential of targeting substance P/NK-1R interactions in inflammatory CNS disorders

MB Johnson, AD Young, I Marriott - Frontiers in cellular neuroscience, 2017 - frontiersin.org
The inflammatory responses of resident central nervous system (CNS) cells are now known
to play a critical role in the initiation and progression of an array of infectious and sterile …

Identification and validation of oxidative stress and immune-related hub genes in Alzheimer's disease through bioinformatics analysis

S Li, J Xiao, C Huang, J Sun - Scientific Reports, 2023 - nature.com
Alzheimer's disease (AD) is the leading cause of dementia in aged population. Oxidative
stress and neuroinflammation play important roles in the pathogenesis of AD. Investigation …

DPP-4 inhibition by linagliptin ameliorates age-related mild cognitive impairment by regulating microglia polarization in mice

F Zhuge, L Zheng, Y Pan, L Ni, Z Fu, J Shi, Y Ni - Experimental Neurology, 2024 - Elsevier
Extensive preclinical evidence demonstrates a causative link between insulin signaling
dysfunction and the pathogenesis of Alzheimer's disease (AD), and diabetic drugs may …

[HTML][HTML] Biochemistry, substance P

SB Graefe, SS Mohiuddin - 2020 - europepmc.org
Substance P is a neuropeptide made up of 11 amino acids—an undecapeptide—and is a
part of the tachykinin neuropeptide family. Its receptor, neurokinin type 1 (NK-1R), is a …

Longitudinal speech biomarkers for automated alzheimer's detection

J Laguarta, B Subirana - frontiers in Computer Science, 2021 - frontiersin.org
We introduce a novel audio processing architecture, the Open Voice Brain Model (OVBM),
improving detection accuracy for Alzheimer's (AD) longitudinal discrimination from …

[HTML][HTML] DPP-4 inhibitors: a promising therapeutic approach against Alzheimer's disease

E Angelopoulou, C Piperi - Annals of translational medicine, 2018 - ncbi.nlm.nih.gov
Abstract Alzheimer's disease (AD), the commonest cause of dementia in ageing adults, is
characterized by gradual cognitive impairment and severe functional disability. Key …