Head and neck cancer is the seventh most common type of cancer worldwide and comprise
of a diverse group of tumours affecting the upper aerodigestive tract. Although many different …

Cancer is the second leading cause of death in the world and one of the major public health
problems. Despite the great advances in cancer therapy, the incidence and mortality rates of …

Recent clinical trials have demonstrated a clear survival advantage in advanced head and
neck squamous cell carcinoma (HNSCC) patients treated with immune checkpoint blockade …

Purpose: The genetic differences between human papilloma virus (HPV)–positive and–
negative head and neck squamous cell carcinomas (HNSCC) remain largely unknown. To …

Hypoxia, a condition of low oxygen tension in tissues, has emerged as a crucial factor in
tumor pathophysiology. Hypoxic microenvironment gives rise to altered cellular metabolism …

Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Purpose: Current classification of head and neck squamous cell carcinomas (HNSCC)
based on anatomic site and stage fails to capture biologic heterogeneity or adequately …

Background We conducted a multinational, randomized study to compare radiotherapy
alone with radiotherapy plus cetuximab, a monoclonal antibody against the epidermal …

Background Despite more than 70 randomised trials, the effect of chemotherapy on non-
metastatic head and neck squamous-cell carcinoma remains uncertain. We did three meta …

Purpose: The Head and Neck Intergroup conducted a phase III randomized trial to test the
benefit of adding chemotherapy to radiation in patients with unresectable squamous cell …