Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

Prion diseases are fatal neurodegenerative disorders of humans and animals that are
important because of their impact on public health and because they exemplify a novel …

The molecular basis of strain variation in scrapie diseases is unknown. The only identified
component of the agent is the posttranslationally modified host prion protein (PrPSc). The …

Transmissible mink encephalopathy (TME) has been transmitted to Syrian golden hamsters,
and two strains of the causative agent, HYPER (HY) and DROWSY (DY), have been …

Antibody response in mice to scrapie-associated fibril proteins (protease-resistant proteins
[PrPs]) was generated to different epitopes depending on the source of antigen. Mice …

The Pm-i gene, controlling scrapie incubation period, is linked to or congruent with the
murine prion protein (PrP) gene, Pm-p. In prototypic mouse strains with long (IILn) and short …

Six subtypes of sporadic Creutzfeldt–Jakob disease with distinctive clinico-pathological
features have been identified largely based on two types of the abnormal prion protein, PrP …

PERSISTENT changes in synaptic efficacy are thought to underlie the formation of learning
and memory in the brain1. High-frequency activation of an afferent excitatory fibre system …

Studies of prion biology and diseases have elucidated several new concepts, but none was
more heretical than the proposal that the biological properties that distinguish different prion …

Prions are unconventional infectious agents responsible for transmissible spongiform
encephalopathies. Compelling evidences indicate that prions are composed exclusively by …