With some indoles and azaindoles being successfully developed as anticancer drugs, the
design and synthesis of indole and azaindole derivatives with remarkable antitumor activity …

Multi-cellular spheroids mimic the complex three-dimensional environment of natural
tissues. Accordingly, they are also used as vascularization units in angiogenesis research …

We report the design, synthesis, and biological evaluation of heterocyclic-fused pyrimidines
as tubulin polymerization inhibitors targeting the colchicine binding site with significantly …

Recently, we reported that Rhus coriaria exhibits anticancer activities by promoting cell cycle
arrest and autophagic cell death of the metastatic triple negative MDA-MB-231 breast cancer …

Background We have recently reported that Origanum majorana exhibits anticancer activity
by promoting cell cycle arrest and apoptosis of the metastatic MDA-MB-231 breast cancer …

Breast cancer (BC) is the second most common cause of cancer-related deaths in women
throughout the world. Multiple drugs have been approved by US-FDA for breast related …

Abstract In 2010, the European Parliament and the European Union adopted a directive on
the protection of animals used for scientific purposes. The directive aims to protect animals …

Polymerization of tubulin dimers to form microtubules is one of the key events in cell
proliferation. The inhibition of this event has long been recognized as a potential treatment …

Antimitotics binding at the colchicine site of tubulin are important antitumour and vascular
disrupting agents. Pyridines and azines are privileged scaffolds in medicinal chemistry and …

The aim of the present work was to address the role of BMP9 in different genetic
backgrounds (C57BL/6, BALB/c, and 129/Ola) of mice deleted for Bmp9. We found that …