Developing new, more effective antibiotics against resistant Mycobacterium tuberculosis that
inhibit its essential proteins is an appealing strategy for combating the global tuberculosis …

The place of prodrugs in the current antitubercular therapeutic arsenal is preponderant,
since two of the four first‐line antitubercular agents, isoniazid (INH) and pyrazinamide (PZA) …

Radical stabilization energies (RSEs) for a wide variety of nitrogen-centered radicals and
their protonated counterparts have been calculated at G3 (MP2)-RAD and G3B3 level. The …

The antituberculosis (anti-TB) drug rifampin (RIF) binds to the beta subunit of the RNA
polymerase (RpoB) of Mycobacterium tuberculosis, but the bactericidal responses triggered …

This paper presents the degradation of the most widely used antibiotics for the treatment of
tuberculosis, isoniazid (INH), by Fenton, photo-Fenton on bench-scale, and solar photo …

The known mode of action of isoniazid (INH) is to inhibit bacterial cell wall synthesis
following activation by the bacterial catalase–peroxidase enzyme KatG in Mycobacterium …

The formation of isonicotinyl-nicotinamide adenine dinucleotide (INH-NAD+) via the
mycobacterial catalase-peroxidase enzyme, KatG, has been described as the major …

Tuberculosis (TB) is one of the leading causes of death due to infectious diseases. Among
the specific drugs currently employed to treat tuberculosis, isoniazid (INH), a pro‐drug …

A complex reaction mechanism of oxidation of the anti-tubercular prodrug isoniazid
(isonicotinic hydrazide, INH) by [IrCl6] 2− as a model for redox processes of such drugs in …

Isoniazid (INH) is one of the most effective antibiotics against tuberculosis. INH is a prodrug
that is activated by KatG. Although extensive studies have been performed in order to …