The advent of epigenetics brought in a tectonic shift in the understanding of molecular basis
of complex diseases like ischemic stroke (IS). Substantial scientific inquiry into the …

Glioblastoma (GBM) is a primary brain tumor arising from glial cells. The tumor is highly
aggressive, the reason for which it has become the deadliest brain tumor type with the …

Abstract WD repeat domain 5 (WDR5) plays an important role in various biological functions
through the epigenetic regulation of gene transcription; however, its role in bladder cancer …

Patients with pancreatic cancer typically develop tumor invasion and metastasis in the early
stage. These malignant behaviors might be originated from cancer stem cells (CSCs), but …

Inducible nitric oxide synthase (iNOS) generates nitric oxide (NO) in myeloid cells that acts
as a defense mechanism to suppress invading microorganisms or neoplastic cells. In tumor …

Mitochondrial changes, including decreased expression of electron transport chain subunit
genes and impaired energetic, have been reported in multiple sclerosis (MS), but the …

Neural stem progenitor cells (NSPCs) in the human subventricular zone (SVZ) potentially
contribute to lifelong neurogenesis, yet subtypes of glioblastoma multiforme (GBM) contain …

Neural stem/progenitor cell (NSPC) self-renewal and differentiation in the developing and
the adult brain are controlled by extra-cellular signals and by the inherent competence of …

Glioblastoma (GBM) is a highly aggressive brain cancer with limited therapeutic options.
While efforts to identify genes responsible for GBM have revealed mutations and aberrant …

The main stem cell niche for neurogenesis in the adult mammalian brain is the
subventricular zone (SVZ) that extends along the cerebral lateral ventricles. We aimed at …