Macrophages are a heterogeneous population of immune cells playing several and diverse
functions in homeostatic and immune responses. The broad spectrum of macrophage …

Metabolic reprogramming has become a key focus for both immunologists and cancer
biologists, with exciting advances providing new insights into the mechanisms underlying …

Thermogenesis by brown and beige adipose tissue, which requires activation by external
stimuli, can counter metabolic disease. Thermogenic respiration is initiated by adipocyte …

In the small intestine, type 2 responses are regulated by a signaling circuit that involves tuft
cells and group 2 innate lymphoid cells (ILC2s). Here, we identified the microbial metabolite …

In addition to their bioenergetic intracellular function, several classical metabolites act as
extracellular signaling molecules activating cell-surface G-protein-coupled receptors …

There is now a wealth of evidence showing that communication between microbiota and the
host is critical to sustain the vital functions of the healthy host, and disruptions of this …

Macrophages activated by the Gram-negative bacterial product lipopolysaccharide switch
their core metabolism from oxidative phosphorylation to glycolysis. Here we show that …

Gut microbiota-related metabolites are potential clinical biomarkers for cardiovascular
disease (CVD). Circulating succinate, a metabolite produced by both microbiota and the …

When SUCNR1/GPR91-expressing macrophages are activated by inflammatory signals,
they change their metabolism and accumulate succinate. In this study, we show that during …

Background Many metabolites serve as important signalling molecules to adjust cellular
activities and functions based on nutrient availability. Links between acetyl-CoA metabolism …