Bladder cancer

L Dyrskjøt, DE Hansel, JA Efstathiou… - Nature Reviews …, 2023 - nature.com
Bladder cancer is a global health issue with sex differences in incidence and prognosis.
Bladder cancer has distinct molecular subtypes with multiple pathogenic pathways …

Recurrence mechanisms of non-muscle-invasive bladder cancer—A clinical perspective

JYC Teoh, AM Kamat, PC Black, P Grivas… - Nature Reviews …, 2022 - nature.com
Non-muscle-invasive bladder cancer (NMIBC) is an early-stage cancer without invasion into
the detrusor muscle layer. Transurethral resection of bladder tumour (TURBT) is a diagnostic …

[HTML][HTML] Construction of self-assembly based tunable absorber: lightweight, hydrophobic and self-cleaning properties

Z Zhou, Q Zhu, Y Liu, Y Zhang, Z Jia, G Wu - Nano-Micro Letters, 2023 - Springer
Although multifunctional aerogels are expected to be used in applications such as portable
electronic devices, it is still a great challenge to confer multifunctionality to aerogels while …

Y chromosome loss in cancer drives growth by evasion of adaptive immunity

HA Abdel-Hafiz, JM Schafer, X Chen, T Xiao… - Nature, 2023 - nature.com
Loss of the Y chromosome (LOY) is observed in multiple cancer types, including 10–40% of
bladder cancers,,,,–, but its clinical and biological significance is unknown. Here, using …

[HTML][HTML] FGFR inhibition augments anti–PD-1 efficacy in murine FGFR3-mutant bladder cancer by abrogating immunosuppression

A Okato, T Utsumi, M Ranieri, X Zheng… - The Journal of …, 2024 - Am Soc Clin Investig
The combination of targeted therapy with immune checkpoint inhibition (ICI) is an area of
intense interest. We studied the interaction of fibroblast growth factor receptor (FGFR) …

[HTML][HTML] Exposure to benzene and other hydrocarbons and risk of bladder cancer among male offshore petroleum workers

NK Shala, JS Stenehjem, R Babigumira, FC Liu… - British Journal of …, 2023 - nature.com
Background Occupational exposures constitute the second leading cause of urinary bladder
cancer after tobacco smoking. Increased risks have been found in the petroleum industry …

[HTML][HTML] Proteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ

Z Yao, N Xu, G Shang, H Wang, H Tao, Y Wang… - Nature …, 2023 - nature.com
The progression of urothelial bladder cancer (UC) is a complicated multi-step process. We
perform a comprehensive multi-omics analysis of 448 samples from 190 UC patients …

SPASCER: spatial transcriptomics annotation at single-cell resolution

Z Fan, Y Luo, H Lu, T Wang, YZ Feng… - Nucleic Acids …, 2023 - academic.oup.com
In recent years, the explosive growth of spatial technologies has enabled the
characterization of spatial heterogeneity of tissue architectures. Compared to traditional …

[HTML][HTML] APOBEC3-mediated mutagenesis in cancer: causes, clinical significance and therapeutic potential

K Butler, AR Banday - Journal of Hematology & Oncology, 2023 - Springer
Apolipoprotein B mRNA-editing enzyme, catalytic polypeptides (APOBECs) are cytosine
deaminases involved in innate and adaptive immunity. However, some APOBEC family …

Circulating and urinary tumour DNA in urothelial carcinoma—Upper tract, lower tract and metastatic disease

KM Rose, HL Huelster, JJ Meeks, BM Faltas… - Nature Reviews …, 2023 - nature.com
Precision medicine has transformed the way urothelial carcinoma is managed. However,
current practices are limited by the availability of tissue samples for genomic profiling and …