Dexmedetomidine, a highly selective α2-adrenoceptor agonist, has sedative, anxiolytic,
analgesic, sympatholytic, and opioid-sparing properties and induces a unique sedative …

Ischemia-reperfusion myocardial damage is a paradoxical tissue injury occurring during
percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) patients …

Ischemia-reperfusion (I/R) injury is a serious clinical pathology associated with acute kidney
injury (AKI). Ferroptosis is non-apoptotic cell death that is known to contribute to renal I/R …

Acetaminophen (APAP) overdose has long been considered a major cause of drug-induced
liver injury. Ferroptosis is a type of programmed cell death mediated by iron-dependent lipid …

BACKGROUND: Myocardial infarction is a common perioperative complication, and blood
flow restoration causes ischemia/reperfusion injury (IRI). Dexmedetomidine (DEX) …

Purpose Endoplasmic reticulum stress (ERS) plays an important role in the pathogenesis of
lung ischemia/reperfusion (I/R) injury. Cyclic GMP-AMP synthase (cGAS) is a cytosol dsDNA …

Traumatic brain injury (TBI) is a major public health problem and a major cause of mortality
and disability that imposes a substantial economic burden worldwide. Dexmedetomidine …

Brown adipose tissue (BAT) plays a critical role in regulating cardiovascular homeostasis
through the secretion of adipokines, such as fibroblast growth factor 21 (FGF21) …

Background The regeneration strategy involves several aspects, such as reprogramming
aspects, targeting pathophysiological processes, and inducing the physiological one …

Background Myocardial ischemia/reperfusion (I/R) injury is a fatal event that usually occurs
after reperfusion therapy for myocardial infarction. Dexmedetomidine (Dex) has been shown …