Axonal regeneration: underlying molecular mechanisms and potential therapeutic targets
Axons in the peripheral nervous system have the ability to repair themselves after damage,
whereas axons in the central nervous system are unable to do so. A common and important …
whereas axons in the central nervous system are unable to do so. A common and important …
Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells
Regulatory programs governing neuronal death and axon regeneration in
neurodegenerative diseases remain poorly understood. In adult mice, optic nerve crush …
neurodegenerative diseases remain poorly understood. In adult mice, optic nerve crush …
Peripheral mechanism of cancer-induced bone pain
Y Yang, W Yang, R Zhang, Y Wang - Neuroscience Bulletin, 2024 - Springer
Cancer-induced bone pain (CIBP) is a type of ongoing or breakthrough pain caused by a
primary bone tumor or bone metastasis. CIBP constitutes a specific pain state with distinct …
primary bone tumor or bone metastasis. CIBP constitutes a specific pain state with distinct …
PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke
A Nakamura, S Sakai, Y Taketomi, J Tsuyama, Y Miki… - Neuron, 2023 - cell.com
The brain is generally resistant to regeneration after damage. The cerebral endogenous
mechanisms triggering brain self-recovery have remained unclarified to date. We here …
mechanisms triggering brain self-recovery have remained unclarified to date. We here …
Bridging the gap of axonal regeneration in the central nervous system: A state of the art review on central axonal regeneration
G Costa, FF Ribeiro, AM Sebastião, EM Muir… - Frontiers in …, 2022 - frontiersin.org
Neuronal regeneration in the central nervous system (CNS) is an important field of research
with relevance to all types of neuronal injuries, including neurodegenerative diseases. The …
with relevance to all types of neuronal injuries, including neurodegenerative diseases. The …
Targeting the peripheral neural-tumour microenvironment for cancer therapy
D Yaniv, B Mattson, S Talbot, FO Gleber-Netto… - Nature Reviews Drug …, 2024 - nature.com
As the field of cancer neuroscience expands, the strategic targeting of interactions between
neurons, cancer cells and other elements in the tumour microenvironment represents a …
neurons, cancer cells and other elements in the tumour microenvironment represents a …
Integrated analysis reveals Atf3 promotes neuropathic pain via orchestrating JunB mediated release of inflammatory cytokines in DRG macrophage
Y Deng, S Tang, J Cheng, X Zhang, D Jing, Z Lin… - Life Sciences, 2023 - Elsevier
The dorsal root ganglion (DRG) is actively involved in the development of neuropathic pain
(NP), serving as an intermediate station for pain signals from the peripheral nervous system …
(NP), serving as an intermediate station for pain signals from the peripheral nervous system …
Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis
The coordination mechanism of neural innate immune responses for axon regeneration is
not well understood. Here, we showed that neuronal deletion of protein tyrosine …
not well understood. Here, we showed that neuronal deletion of protein tyrosine …
Endothelial miR-196b-5p regulates angiogenesis via the hypoxia/miR-196b-5p/HMGA2/HIF1α loop
R Ren, K Ma, Y Jiang, J Chen, Y Kou… - … of Physiology-Cell …, 2023 - journals.physiology.org
Angiogenesis is involved in development, reproduction, wound healing, homeostasis, and
other pathophysiological events. Imbalanced angiogenesis predisposes patients to various …
other pathophysiological events. Imbalanced angiogenesis predisposes patients to various …
[HTML][HTML] Cisplatin induced alterations in nociceptor developmental trajectory elicits a TrkA dependent platinum-based chemotherapy induced neuropathic pain
L Hardowar, T Valentine, MDV Lobo, J Corbett, B Owen… - Neuroscience, 2024 - Elsevier
Cisplatin-based chemotherapy is a common treatment for paediatric cancer. Unfortunately,
cisplatin treatment causes neuropathic pain, a highly prevalent adverse health related …
cisplatin treatment causes neuropathic pain, a highly prevalent adverse health related …