Axonal regeneration: underlying molecular mechanisms and potential therapeutic targets

R Akram, H Anwar, MS Javed, A Rasul, A Imran… - Biomedicines, 2022 - mdpi.com
Axons in the peripheral nervous system have the ability to repair themselves after damage,
whereas axons in the central nervous system are unable to do so. A common and important …

Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells

F Tian, Y Cheng, S Zhou, Q Wang, A Monavarfeshani… - Neuron, 2022 - cell.com
Regulatory programs governing neuronal death and axon regeneration in
neurodegenerative diseases remain poorly understood. In adult mice, optic nerve crush …

Peripheral mechanism of cancer-induced bone pain

Y Yang, W Yang, R Zhang, Y Wang - Neuroscience Bulletin, 2024 - Springer
Cancer-induced bone pain (CIBP) is a type of ongoing or breakthrough pain caused by a
primary bone tumor or bone metastasis. CIBP constitutes a specific pain state with distinct …

PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke

A Nakamura, S Sakai, Y Taketomi, J Tsuyama, Y Miki… - Neuron, 2023 - cell.com
The brain is generally resistant to regeneration after damage. The cerebral endogenous
mechanisms triggering brain self-recovery have remained unclarified to date. We here …

Bridging the gap of axonal regeneration in the central nervous system: A state of the art review on central axonal regeneration

G Costa, FF Ribeiro, AM Sebastião, EM Muir… - Frontiers in …, 2022 - frontiersin.org
Neuronal regeneration in the central nervous system (CNS) is an important field of research
with relevance to all types of neuronal injuries, including neurodegenerative diseases. The …

Targeting the peripheral neural-tumour microenvironment for cancer therapy

D Yaniv, B Mattson, S Talbot, FO Gleber-Netto… - Nature Reviews Drug …, 2024 - nature.com
As the field of cancer neuroscience expands, the strategic targeting of interactions between
neurons, cancer cells and other elements in the tumour microenvironment represents a …

Integrated analysis reveals Atf3 promotes neuropathic pain via orchestrating JunB mediated release of inflammatory cytokines in DRG macrophage

Y Deng, S Tang, J Cheng, X Zhang, D Jing, Z Lin… - Life Sciences, 2023 - Elsevier
The dorsal root ganglion (DRG) is actively involved in the development of neuropathic pain
(NP), serving as an intermediate station for pain signals from the peripheral nervous system …

Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis

X Wang, C Yang, X Wang, J Miao, W Chen, Y Zhou… - Neuron, 2023 - cell.com
The coordination mechanism of neural innate immune responses for axon regeneration is
not well understood. Here, we showed that neuronal deletion of protein tyrosine …

Endothelial miR-196b-5p regulates angiogenesis via the hypoxia/miR-196b-5p/HMGA2/HIF1α loop

R Ren, K Ma, Y Jiang, J Chen, Y Kou… - … of Physiology-Cell …, 2023 - journals.physiology.org
Angiogenesis is involved in development, reproduction, wound healing, homeostasis, and
other pathophysiological events. Imbalanced angiogenesis predisposes patients to various …

[HTML][HTML] Cisplatin induced alterations in nociceptor developmental trajectory elicits a TrkA dependent platinum-based chemotherapy induced neuropathic pain

L Hardowar, T Valentine, MDV Lobo, J Corbett, B Owen… - Neuroscience, 2024 - Elsevier
Cisplatin-based chemotherapy is a common treatment for paediatric cancer. Unfortunately,
cisplatin treatment causes neuropathic pain, a highly prevalent adverse health related …