Vaccine nanoparticles for protection against HIV infection
The development of a successful vaccine against HIV is a major global challenge.
Antiretroviral therapy is the standard treatment against HIV-1 infection. However, only 46 …
Antiretroviral therapy is the standard treatment against HIV-1 infection. However, only 46 …
Liposomal vaccines incorporating molecular adjuvants and intrastructural T-cell help promote the immunogenicity of HIV membrane-proximal external region peptides
An HIV vaccine capable of inducing high and durable levels of broadly neutralizing
antibodies has thus far proven elusive. A promising antigen is the membrane-proximal …
antibodies has thus far proven elusive. A promising antigen is the membrane-proximal …
Liposome-based peptide vaccines to elicit immune responses against the membrane active domains of the HIV-1 Env glycoprotein
The fusion peptide (FP) and the Trp-rich membrane proximal external region (MPER)
display membrane activity during HIV-1 fusion. These domains are highly conserved in the …
display membrane activity during HIV-1 fusion. These domains are highly conserved in the …
Tyrosine O-sulfation proteoforms affect HIV-1 monoclonal antibody potency
CX Cai, NA Doria-Rose, NA Schneck, VB Ivleva… - Scientific Reports, 2022 - nature.com
Abstract CAP256V2LS, a broadly neutralizing monoclonal antibody (bNAb), is being
pursued as a promising drug for HIV-1 prevention. The total level of tyrosine-O-sulfation, a …
pursued as a promising drug for HIV-1 prevention. The total level of tyrosine-O-sulfation, a …
The Atomic Structure of the HIV-1 gp41 Transmembrane Domain and Its Connection to the Immunogenic Membrane-proximal External Region*♦
B Apellániz, E Rujas, S Serrano, K Morante… - Journal of Biological …, 2015 - ASBMB
The membrane-proximal external region (MPER) C-terminal segment and the
transmembrane domain (TMD) of gp41 are involved in HIV-1 envelope glycoprotein …
transmembrane domain (TMD) of gp41 are involved in HIV-1 envelope glycoprotein …
An engineered biomimetic MPER peptide vaccine induces weakly HIV neutralizing antibodies in mice
S Shao, WC Huang, C Lin, MD Hicar… - Annals of biomedical …, 2020 - Springer
A vaccine that induces broadly neutralizing antibodies (bnAbs) against the human
immunodeficiency virus (HIV) would be instrumental in controlling the disease. The …
immunodeficiency virus (HIV) would be instrumental in controlling the disease. The …
The use of liposomes to shape epitope structure and modulate immunogenic responses of peptide vaccines against HIV MPER
B Apellániz, JL Nieva - Advances in protein chemistry and structural biology, 2015 - Elsevier
Peptide vaccines have been shown effective in preventing animal infection in some
instances, and various formulations are under evaluation for their potential clinical use in …
instances, and various formulations are under evaluation for their potential clinical use in …
Anti-MPER antibodies with heterogeneous neutralization capacity are detectable in most untreated HIV-1 infected individuals
LM Molinos-Albert, J Carrillo, M Curriu… - Retrovirology, 2014 - Springer
Background The MPER region of the HIV-1 envelope glycoprotein gp41 is targeted by
broadly neutralizing antibodies. However, the localization of this epitope in a hydrophobic …
broadly neutralizing antibodies. However, the localization of this epitope in a hydrophobic …
Sterol-modified PEG lipids: Alteration of the bilayer anchoring moiety has an unexpected effect on liposome circulation
A Dolor, P Kierstead, Z Dai, FC Szoka - Chemical Communications, 2018 - pubs.rsc.org
We synthesized and characterized two novel sterol-anchored polyethylene glycols (PEG) as
potential alternatives to conventional phosphatidylethanolamine-PEGs. Liposomes …
potential alternatives to conventional phosphatidylethanolamine-PEGs. Liposomes …
DNA vaccine-encoded flagellin can be used as an adjuvant scaffold to augment HIV-1 gp41 membrane proximal external region immunogenicity
L Ajamian, L Melnychuk, P Jean-Pierre, GJ Zaharatos - Viruses, 2018 - mdpi.com
Flagellin's potential as a vaccine adjuvant has been increasingly explored over the last three
decades. Monomeric flagellin proteins are the only known agonists of Toll-like receptor 5 …
decades. Monomeric flagellin proteins are the only known agonists of Toll-like receptor 5 …