Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …

Regulation of intracellular calcium (Ca 2+) is critical in all cell types. The ryanodine receptor
(RyR), an intracellular Ca 2+ release channel located on the sarco/endoplasmic reticulum …

The effects of the immunophilins, FKBP12 and FKBP12. 6, and phosphorylation on type II
ryanodine receptor (RyR2) arrangement and function were examined using correlation …

The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …

The sarcoplasmic reticulum (SR) is crucial for contraction and relaxation of the mammalian
cardiomyocyte, but its role in other vertebrate classes is equivocal. Recent evidence …

In many cell types the intracellular Ca2+ store performs a central role in the regulation of the
cytosolic Ca2+ concentration ([Ca2+] c), the elevation of which triggers diverse and …

Aims Connexin-based gap junctions are crucial for electrical communication in the heart;
they are each composed of two docked hemichannels (HCs), supplied as unpaired …

Cardiac ryanodine receptors (RyR2) release the Ca2+ from intracellular stores that is
essential for cardiac myocyte contraction. The ion channel opening is tightly regulated by …

Abstract Aim Inositol 1, 4, 5‐trisphosphate receptors (IP3Rs) are intracellular Ca2+‐release
channels with crucial roles in cell function. Current IP3R inhibitors suffer from off‐target …

Dantrolene is a neutral hydantoin that is clinically used as a skeletal muscle relaxant to
prevent overactivation of the skeletal muscle calcium release channel (RyR1) in response to …