A large body of experimental evidence suggests that neuroinflammation is a key
pathological event triggering and perpetuating the neurodegenerative process associated …

Inflammation clearly occurs in pathologically vulnerable regions of the Alzheimer's disease
(AD) brain, and it does so with the full complexity of local peripheral inflammatory responses …

▪ Abstract Cyclooxygenase (COX), first purified in 1976 and cloned in 1988, is the key
enzyme in the synthesis of prostaglandins (PGs) from arachidonic acid. In 1991, several …

Cyclooxygenase (COX), the key enzyme required for the conversion of arachidonic acid to
prostaglandins was first identified over 20 years ago. Drugs, like aspirin, that inhibit …

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS).
Microglia are the resident innate immune cells in the CNS; they play an important role in the …

Drosophila NF-κB homologue “dorsal” is required for establishment of dorso-ventral polarity
in the developing embryo (7). In the developing rat nervous system, levels of NF-κB activity …

Generation and deposition of amyloid beta peptides and neurofibrillary tangle formation are
key mechanisms involved in AD pathogenesis. Recent evidence suggests that inflammatory …

Prostaglandins are formed from arachidonic acid by the action of cyclooxygenase and
subsequent downstream synthetases. Two closely related forms of the cyclooxygenase have …

Generation of neurotoxic amyloid β peptides and their deposition along with neurofibrillary
tangle formation represent key pathological hallmarks in Alzheimer's disease (AD). Recent …

▪ Abstract Cyclooxygenase (COX), also known as prostaglandin endoperoxide synthase, is
the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two COX …