Current status and contemporary approaches to the discovery of antitumor agents from higher plants
G Agarwal, PJB Carcache, EM Addo… - Biotechnology advances, 2020 - Elsevier
Higher plant constituents have afforded clinically available anticancer drugs. These include
both chemically unmodified small molecules and their synthetic derivatives currently used or …
both chemically unmodified small molecules and their synthetic derivatives currently used or …
[HTML][HTML] Structure, function and biogenesis of the fungal proton pump Pma1
M Young, S Heit, M Bublitz - … et Biophysica Acta (BBA)-Molecular Cell …, 2023 - Elsevier
The fungal plasma membrane proton pump Pma1 is an integral plasma membrane protein
of the P-type ATPase family. It is an essential enzyme responsible for maintaining a constant …
of the P-type ATPase family. It is an essential enzyme responsible for maintaining a constant …
Investigation of the Mechanism and Chemistry Underlying Staphylococcus aureus' Ability to Inhibit Pseudomonas aeruginosa Growth In Vitro
Pseudomonas aeruginosa inhibits or eradicates Staphylococcus aureus in most in vitro
settings. Nonetheless, P. aeruginosa and S. aureus are commonly isolated from chronically …
settings. Nonetheless, P. aeruginosa and S. aureus are commonly isolated from chronically …
Magnetic Ligand Fishing as a Targeting Tool for HPLC-HRMS-SPE-NMR: α-Glucosidase Inhibitory Ligands and Alkylresorcinol Glycosides from Eugenia catharinae
SG Wubshet, IMC Brighente, R Moaddel… - Journal of Natural …, 2015 - ACS Publications
A bioanalytical platform combining magnetic ligand fishing for α-glucosidase inhibition
profiling and HPLC-HRMS-SPE-NMR for structural identification of α-glucosidase inhibitory …
profiling and HPLC-HRMS-SPE-NMR for structural identification of α-glucosidase inhibitory …
High-resolution α-amylase assay combined with high-performance liquid chromatography–solid-phase extraction–nuclear magnetic resonance spectroscopy for …
L Okutan, KT Kongstad, AK Jäger… - Journal of agricultural …, 2014 - ACS Publications
Type 2 diabetes affects millions of people worldwide, and new improved drugs or functional
foods containing selective α-amylase inhibitors are needed for improved management of …
foods containing selective α-amylase inhibitors are needed for improved management of …
Identification of Antifungal H+-ATPase Inhibitors with Effect on Plasma Membrane Potential
L Kjellerup, S Gordon, KOH Cohrt… - Antimicrobial Agents …, 2017 - Am Soc Microbiol
The plasma membrane H+-ATPase (Pma1) is an essential fungal protein and a proposed
target for new antifungal medications. The compounds in a small-molecule library …
target for new antifungal medications. The compounds in a small-molecule library …
Identification of PTP1B and α-Glucosidase Inhibitory Serrulatanes from Eremophila spp. by Combined use of Dual High-Resolution PTP1B and α-Glucosidase …
SG Wubshet, Y Tahtah, AM Heskes… - Journal of Natural …, 2016 - ACS Publications
According to the International Diabetes Federation, type 2 diabetes (T2D) has reached
epidemic proportions, affecting more than 382 million people worldwide. Inhibition of protein …
epidemic proportions, affecting more than 382 million people worldwide. Inhibition of protein …
High-resolution PTP1B inhibition profiling combined with high-performance liquid chromatography–high-resolution mass spectrometry–solid-phase extraction …
Y Tahtah, SG Wubshet, KT Kongstad, AM Heskes… - Fitoterapia, 2016 - Elsevier
Abstract Type 2 diabetes (T2D) constituted 90% of the global 387 million diabetes cases in
2014. The enzyme protein-tyrosine phosphatase 1B (PTP1B) has been recognized as a …
2014. The enzyme protein-tyrosine phosphatase 1B (PTP1B) has been recognized as a …
Combined use of high-resolution α-glucosidase inhibition profiling and high-performance liquid chromatography–high-resolution mass spectrometry–solid-phase …
KT Kongstad, C Özdemir, A Barzak… - Journal of agricultural …, 2015 - ACS Publications
Type 2 diabetes is a metabolic disorder affecting millions of people worldwide, and new
drug leads or functional foods containing selective α-glucosidase inhibitors are needed …
drug leads or functional foods containing selective α-glucosidase inhibitors are needed …
Triple aldose reductase/α-glucosidase/radical scavenging high-resolution profiling combined with high-performance liquid chromatography–high-resolution mass …
Y Tahtah, KT Kongstad, SG Wubshet, NT Nyberg… - … of Chromatography A, 2015 - Elsevier
In this work, development of a new microplate-based high-resolution profiling assay using
recombinant human aldose reductase is presented. Used together with high-resolution …
recombinant human aldose reductase is presented. Used together with high-resolution …