Substitution of a hydrogen atom with its heavy isotope deuterium entails the addition of one
neutron to a molecule. Despite being a subtle change, this structural modification, known as …

Atopic dermatitis (AD) is a chronic, inflammatory, pruritic form of dermatosis with
heterogeneous manifestations that can substantially affect patients' quality of life. AD has a …

Objective To evaluate the long-term safety profile for upadacitinib across rheumatoid arthritis
(RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS) and atopic dermatitis (AD) …

Objectives To provide an integrated analysis of major adverse cardiovascular events
(MACEs) and events of venous thromboembolism (VTE) and associated risk factors across …

Janus kinase (JAK) inhibitors have been recently approved by the FDA and are widely used
in the treatment of patients with atopic dermatitis. However, a comprehensive safety profile of …

Myelofibrosis (MF) is a chronic myeloproliferative neoplasm characterized by bone marrow
fibrosis, anemia, extramedullary hematopoiesis, and splenomegaly. Patients with MF are at …

Introduction The benefit/risk profiles of biologics can be affected by comorbidities, certain
demographic characteristics, and concomitant medications; therefore, it is important to …

Janus kinase inhibitors (JAKi) have enormous appeal as immune-modulating therapies
across many chronic inflammatory diseases, but recently this promise has been …

Janus kinase (JAK) plays a crucial role in intracellular signaling pathways, particularly in
cytokine-mediated signal transduction, making them attractive therapeutic targets for a wide …

Introduction Numerous cutaneous dermatoses mediated by cytokines depend on the JAK
STAT pathway for intracellular signaling. JAK inhibitors form a useful therapeutic approach …