The native extracellular matrix (ECM) generally exhibits dynamic mechanical properties and
displays time‐dependent responses to deformation or mechanical loading, in terms of …

Nanoindentation techniques, with high spatial resolution and force sensitivity, have recently
been moved into the center of the spotlight for measuring the mechanical properties of …

Emerging heart-on-a-chip platforms are promising approaches to establish cardiac
cell/tissue models in vitro for research on cardiac physiology, disease modeling and drug …

Myocardial stiffness is an intrinsic property of the myocardium that influences both diastolic
and systolic cardiac function. Myocardial stiffness represents the resistance of this tissue to …

Relevant, predictive normal, or disease model systems are of vital importance for drug
development. The difference between nonhuman models and humans could contribute to …

Increased myocardial stiffness is critically involved in heart diseases with impaired cardiac
compliance, especially heart failure with preserved ejection fraction (HFpEF). Myocardial …

Cardiomyocytes sense and shape their mechanical environment, contributing to its
dynamics by their passive and active mechanical properties. While axial forces generated by …

Cardiomyocytes are the motor units that drive the contraction and relaxation of the heart.
Traditionally, testing of drugs for cardiotoxic effects has relied on primary cardiomyocytes …

Cardiomyocytes generate force for the contraction of the heart to pump blood into the lungs
and body. At the same time, they are exquisitely tuned to the mechanical environment and …

A comprehensive understanding of the cardiac structure–function relationship is essential
for proper clinical cardiac imaging. This review summarizes the basic heart anatomy and …