Heterochromatin was first defined by Emil Heitz in 1928 by light microscopy. In the 1950s
electron microscopy studies revealed that heterochromatin preferentially localizes to the …

Skin undergoes continuous renewal throughout an individual's lifetime relying on stem cell
functionality. However, a decline of the skin regenerative potential occurs with age. The …

Introduction: Hypermethylation of genes associated with promoter CpG islands, and
hypomethylation of CpG poor genes, repeat sequences, transposable elements and …

The epidermis is a self-renewing tissue. The balance between proliferation and
differentiation processes is tightly regulated to ensure the maintenance of the stem cell (SC) …

The complex life cycle of oncogenic human papillomavirus (HPV) initiates in undifferentiated
basal epithelial keratinocytes where expression of the E6 and E7 oncogenes is restricted …

Architectural proteins are essential epigenetic regulators that play a critical role in
organizing chromatin and controlling gene expression. CTCF (CCCTC-binding factor) is a …

This textbook is designed to be a comprehensive assessment of current knowledge
regarding the surgical and general pathology of hepatobiliary tumors and tumor-like lesions …

Fifteen years ago, we reported that proto-oncogene MYC promoted differentiation of human
epidermal stem cells, a finding that was surprising to the MYC and the skin research …

The skin of most mammals is characterised by the presence of sebaceous glands (SG s),
whose predominant constituent cell population is sebocytes, that is, lipid‐producing …

Tumor suppressor p53 is a major cellular guardian of genome integrity, and its inactivation is
the most frequent genetic alteration in cancer, rising up to 80% in squamous cell carcinoma …