How do lncRNAs regulate transcription?
It has recently become apparent that RNA, itself the product of transcription, is a major
regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs) …
regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs) …
Transcription regulation by long non-coding RNAs: mechanisms and disease relevance
J Ferrer, N Dimitrova - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …
Histone lysine methylation dynamics: establishment, regulation, and biological impact
JC Black, C Van Rechem, JR Whetstine - Molecular cell, 2012 - cell.com
Histone lysine methylation has emerged as a critical player in the regulation of gene
expression, cell cycle, genome stability, and nuclear architecture. Over the past decade, a …
expression, cell cycle, genome stability, and nuclear architecture. Over the past decade, a …
Epigenetic modifications: basic mechanisms and role in cardiovascular disease
DE Handy, R Castro, J Loscalzo - Circulation, 2011 - Am Heart Assoc
The term epigenetics was first used to refer to the complex interactions between the genome
and the environment that are involved in development and differentiation in higher …
and the environment that are involved in development and differentiation in higher …
Child health, developmental plasticity, and epigenetic programming
Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …
survival and reproductive success to the organism under changing environments …
H3K9 methyltransferase G9a and the related molecule GLP
Y Shinkai, M Tachibana - Genes & development, 2011 - genesdev.cshlp.org
The discovery of Suv39h1, the first SET domain-containing histone lysine methyltransferase
(HKMT), was reported in 2000. Since then, research on histone methylation has progressed …
(HKMT), was reported in 2000. Since then, research on histone methylation has progressed …
Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation
Recent investigations have implicated long antisense noncoding RNAs in the epigenetic
regulation of chromosomal domains. Here we show that Kcnq1ot1 is an RNA polymerase II …
regulation of chromosomal domains. Here we show that Kcnq1ot1 is an RNA polymerase II …
The H19 locus: Role of an imprinted non‐coding RNA in growth and development
A Gabory, H Jammes, L Dandolo - Bioessays, 2010 - Wiley Online Library
The H19 gene produces a non‐coding RNA, which is abundantly expressed during
embryonic development and down‐regulated after birth. Although this gene was discovered …
embryonic development and down‐regulated after birth. Although this gene was discovered …
In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions
S Quenneville, G Verde, A Corsinotti, A Kapopoulou… - Molecular cell, 2011 - cell.com
The maintenance of H3K9 and DNA methylation at imprinting control regions (ICRs) during
early embryogenesis is key to the regulation of imprinted genes. Here, we reveal that ZFP57 …
early embryogenesis is key to the regulation of imprinted genes. Here, we reveal that ZFP57 …
The Air Noncoding RNA Epigenetically Silences Transcription by Targeting G9a to Chromatin
A number of large noncoding RNAs (ncRNAs) epigenetically silence genes through
unknown mechanisms. The Air ncRNA is imprinted—monoallelically expressed from the …
unknown mechanisms. The Air ncRNA is imprinted—monoallelically expressed from the …