Research on the molecular pathology of genome instability disorders has advanced our
understanding of the complex mechanisms that safeguard genome stability and cellular …

Mitosis is the process of cell division and is regulated by checkpoints in the cell cycle. G1-S,
S, and G2-M are the three main checkpoints that prevent initiation of the next phase of the …

ATM (ataxia-telangiectasia mutated) is a PI3K-like kinase best known for its role in the DNA
damage response (DDR), especially after double-strand breaks. Mutations in the ATM gene …

Ataxia-telangiectasia (AT) is an autosomal recessive disease caused by mutation of the ATM
gene and is characterized by loss of cerebellar Purkinje cells, neurons with high …

ABSTRACT ATM (ataxia telangiectasia mutated) protein is found associated with multiple
organelles including synaptic vesicles, endosomes and lysosomes, often in cooperation with …

Adult-onset neurodegenerative diseases are often accompanied by evidence of a chronic
inflammation that includes activation of microglial cells and altered levels of brain cytokines …

Purpose: Glioblastoma (GBM) is one of the most aggressive and lethal cancer types in
humans. The standard treatment approach is surgery followed by chemoradiation. However …

Accumulating evidence indicates that ataxia-telangiectasia mutated kinase is critical for
maintaining cellular homeostasis and that it has both nuclear and cytoplasmic functions …

Interest in the function of ataxia-telangiectasia-mutated protein (ATM) is extensively growing
as evidenced by preclinical studies that continuously link ATM with new intracellular …

The trans-Golgi network (TGN) and endosomes are essential protein sorting stations in the
secretory transport pathway. Protein sorting is fundamentally a process of spatial …