A review of Dengvaxia®: development to deployment

SJ Thomas, IK Yoon - Human vaccines & immunotherapeutics, 2019 - Taylor & Francis
Dengue is the world's most prevalent and important arboviral disease. More than 50% of the
world's population lives at daily risk of infection and it is estimated more than 95 million …

Is new dengue vaccine efficacy data a relief or cause for concern?

SJ Thomas - npj Vaccines, 2023 - nature.com
Dengue is a major global public health problem requiring a safe and efficacious vaccine as
the foundation of a comprehensive countermeasure strategy. Despite decades of attempts …

Dengue fever: causes, complications, and vaccine strategies

N Khetarpal, I Khanna - Journal of immunology research, 2016 - Wiley Online Library
Dengue is a highly endemic infectious disease of the tropical countries and is rapidly
becoming a global burden. It is caused by any of the 4 serotypes of dengue virus and is …

Vaccines for the 21st century

I Delany, R Rappuoli, E De Gregorio - EMBO molecular medicine, 2014 - embopress.org
In the last century, vaccination has been the most effective medical intervention to reduce
death and morbidity caused by infectious diseases. It is believed that vaccines save at least …

New insights into the immunopathology and control of dengue virus infection

G Screaton, J Mongkolsapaya, S Yacoub… - Nature Reviews …, 2015 - nature.com
Dengue virus poses a major threat to global public health: two-thirds of the world's
population is now at risk from infection by this mosquito-borne virus. Dengue virus causes a …

From research to phase III: preclinical, industrial and clinical development of the Sanofi Pasteur tetravalent dengue vaccine

B Guy, B Barrere, C Malinowski, M Saville, R Teyssou… - Vaccine, 2011 - Elsevier
Dengue vaccine development has reached a major milestone with the initiation, in 2010, of
the first phase III clinical trial to investigate the Sanofi Pasteur CYD tetravalent dengue …

Dengue vaccine: hypotheses to understand CYD-TDV-induced protection

B Guy, N Jackson - Nature Reviews Microbiology, 2016 - nature.com
Dengue virus (DENV) is a human pathogen with a large impact on public health. Although
no vaccine against DENV is currently licensed, a recombinant vaccine—chimeric yellow …

Preclinical and clinical development of YFV 17D-based chimeric vaccines against dengue, West Nile and Japanese encephalitis viruses

B Guy, F Guirakhoo, V Barban, S Higgs, TP Monath… - Vaccine, 2010 - Elsevier
Dengue viruses (DENV), West Nile virus (WNV) and Japanese encephalitis virus (JEV) are
major global health and growing medical problems. While a live-attenuated vaccine exists …

[HTML][HTML] Development of the Sanofi Pasteur tetravalent dengue vaccine: One more step forward

B Guy, O Briand, J Lang, M Saville, N Jackson - Vaccine, 2015 - Elsevier
Sanofi Pasteur has developed a recombinant, live-attenuated, tetravalent dengue vaccine
(CYD-TDV) that is in late-stage development. The present review summarizes the different …

[HTML][HTML] Current development and challenges of tetravalent live-attenuated dengue vaccines

J Hou, W Ye, J Chen - Frontiers in Immunology, 2022 - frontiersin.org
Dengue is the most common arboviral disease caused by one of four distinct but closely
related dengue viruses (DENV) and places significant economic and public health burdens …