Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
Structural biology of SARS-CoV-2: open the door for novel therapies
W Yan, Y Zheng, X Zeng, B He, W Cheng - Signal Transduction and …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …
Structural insights into SARS-CoV-2 proteins
The unprecedented scale of the ongoing COVID-19 pandemic has catalyzed an intense
effort of the global scientific community to unravel different aspects of the disease in a short …
effort of the global scientific community to unravel different aspects of the disease in a short …
COVID-19 and SARS-CoV-2. Modeling the present, looking at the future
E Estrada - Physics reports, 2020 - Elsevier
Abstract Since December 2019 the Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) has produced an outbreak of pulmonary disease which has soon become a …
(SARS-CoV-2) has produced an outbreak of pulmonary disease which has soon become a …
[HTML][HTML] A structural view of the SARS-CoV-2 virus and its assembly
NJ Hardenbrook, P Zhang - Current opinion in virology, 2022 - Elsevier
Highlights•Structural biology plays a vital role in SARS-CoV-2 vaccine and treatment.•High-
resolution structures of SARS-CoV-2 proteins and complexes have been obtained.•In situ …
resolution structures of SARS-CoV-2 proteins and complexes have been obtained.•In situ …
Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics
Nsp15, a uridine specific endoribonuclease conserved across coronaviruses, processes
viral RNA to evade detection by host defense systems. Crystal structures of Nsp15 from …
viral RNA to evade detection by host defense systems. Crystal structures of Nsp15 from …
SARS-CoV-2 non-structural proteins and their roles in host immune evasion
Coronavirus disease 2019 (COVID-19) has caused an unprecedented global crisis and
continues to threaten public health. The etiological agent of this devastating pandemic …
continues to threaten public health. The etiological agent of this devastating pandemic …
Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U
Nsp15 is a uridine specific endoribonuclease that coronaviruses employ to cleave viral RNA
and evade host immune defense systems. Previous structures of Nsp15 from across …
and evade host immune defense systems. Previous structures of Nsp15 from across …
Coronaviral RNA-methyltransferases: function, structure and inhibition
R Nencka, J Silhan, M Klima, T Otava… - Nucleic acids …, 2022 - academic.oup.com
Abstract Coronaviral methyltransferases (MTases), nsp10/16 and nsp14, catalyze the last
two steps of viral RNA-cap creation that takes place in cytoplasm. This cap is essential for …
two steps of viral RNA-cap creation that takes place in cytoplasm. This cap is essential for …
Azole-Induced Color Vision Deficiency Associated with Thyroid Hormone Signaling: An Integrated In Vivo, In Vitro, and In Silico Study
ZF Chen, ZC Lin, SQ Lu, XF Chen… - Environmental …, 2022 - ACS Publications
Azoles that are used in pesticides, pharmaceuticals, and personal care products can have
toxic effects on fish. However, there is no information regarding azole-induced visual …
toxic effects on fish. However, there is no information regarding azole-induced visual …