The metabolic basis of epilepsy

JM Rho, D Boison - Nature Reviews Neurology, 2022 - nature.com
The brain is a highly energy-demanding organ and requires bioenergetic adaptability to
balance normal activity with pathophysiological fuelling of spontaneous recurrent seizures …

Ketogenic diet: a new light shining on old but gold biochemistry

R Longo, C Peri, D Cricrì, L Coppi, D Caruso, N Mitro… - Nutrients, 2019 - mdpi.com
Diets low in carbohydrates and proteins and enriched in fat stimulate the hepatic synthesis
of ketone bodies (KB). These molecules are used as alternative fuel for energy production in …

[HTML][HTML] Sudden unexpected death in epilepsy: The neuro-cardio-respiratory connection

TA Manolis, AA Manolis, H Melita, AS Manolis - Seizure, 2019 - Elsevier
Sudden unexpected death in epilepsy (SUDEP) is the major cause of epilepsy-related
premature mortality which targets preferentially younger people. Its etiology remains …

Polyunsaturated fatty acids and suicide risk in mood disorders: A systematic review

M Pompili, L Longo, G Dominici, G Serafini… - Progress in neuro …, 2017 - Elsevier
Deficiency of omega-3 polyunsaturated fatty acids (PUFAs) and an alteration between the
ratio of omega-3 and omega-6 PUFAs may contribute to the pathogenesis of bipolar …

Investigating owner use of dietary supplements in dogs with idiopathic epilepsy

BA Berk, RMA Packer, TH Law, HA Volk - Research in veterinary science, 2018 - Elsevier
Epilepsy is the most common chronic neurological disorder in dogs. Some diets have been
shown to have a positive impact upon the seizure activity in dogs with idiopathic epilepsy …

[HTML][HTML] A switch to polyunsaturated fatty acid based ketogenic diet improves seizure control in patients with drug-resistant epilepsy on the mixed fat ketogenic diet: a …

J Nathan, S Bailur, K Datay, S Sharma, DK Kale - Cureus, 2019 - ncbi.nlm.nih.gov
Methods The study evaluated the medical paper record forms of patients who had at least
one seizure per week despite the use of MFKD. These patients were started on PUFA-KD …

A review of recruitment, adherence and drop-out rates in omega-3 polyunsaturated fatty acid supplementation trials in children and adolescents

ISM Van der Wurff, BJ Meyer, RHM De Groot - Nutrients, 2017 - mdpi.com
Introduction: The influence of n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA)
supplementation on health outcomes has been studied extensively with randomized …

The ω-3 endocannabinoid docosahexaenoyl ethanolamide reduces seizure susceptibility in mice by activating cannabinoid type 1 receptors

MM Ghanbari, AG Loron, M Sayyah - Brain Research Bulletin, 2021 - Elsevier
Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are the most recognized
omega-3 unsaturated fatty acids showing neuroprotective activity in animal and clinical …

[PDF][PDF] Dietary supplements in children

SC Smolinske - Pediatr. Clin. N. Am, 2017 - apim.org
Dietary supplements are a form of complementary and alternative medicine (CAM) that
include amino acids, biological/animal extracts, herbals, minerals, and vitamins …

[HTML][HTML] In Silico Screening Identification of Fatty Acids and Fatty Acid Derivatives with Antiseizure Activity: In Vitro and In Vivo Validation

EM Barrionuevo, E Peralta, AM De Nardi… - …, 2024 - pmc.ncbi.nlm.nih.gov
High fat diets have been used as complementary treatments for seizure disorders for more
than a century. Moreover, many fatty acids and derivatives, including the broad-spectrum …