Tyrosinase inhibitors naturally present in plants and synthetic modifications of these natural products as anti-melanogenic agents: a review
Tyrosinase is a key enzyme target to design new chemical ligands against melanogenesis.
In the current review, different chemical derivatives are explored which have been used as …
In the current review, different chemical derivatives are explored which have been used as …
Non-animal models in dermatological research
E Dellambra, T Odorisio, D D'Arcangelo… - ALTEX-Alternatives to …, 2019 - altex.org
Despite being widely used for basic and preclinical studies in dermatology, available animal
models only partly recapitulate human skin features, often leading to disappointing outputs …
models only partly recapitulate human skin features, often leading to disappointing outputs …
Synthesis and discovery of potential tyrosinase inhibitor of new coumarin‐based thiophenyl‐pyrazolylthiazole nuclei: In vitro evaluation, cytotoxicity, kinetic, and …
N Hosseini Nasab, H Raza, YS Eom… - Chemical Biology & …, 2023 - Wiley Online Library
A well‐known key enzyme in melanogenesis and hyperpigmentation is tyrosinase. The
present study introduces a novel series of thiophenyl‐pyrazolylthiazole‐coumarin hybrids …
present study introduces a novel series of thiophenyl‐pyrazolylthiazole‐coumarin hybrids …
The inhibitory effect of polyphenon 60 from green tea on melanin and tyrosinase in zebrafish and a375 human melanoma cells
Polyphenon 60 (PP60) from green tea has long been used as an antioxidant, anticancer,
antimicrobial, and antimutagenic. Aim of the Study. To investigate tyrosinase inhibition …
antimicrobial, and antimutagenic. Aim of the Study. To investigate tyrosinase inhibition …
[HTML][HTML] Novel 1, 2, 4-triazole analogues as mushroom tyrosinase inhibitors: Synthesis, kinetic mechanism, cytotoxicity and computational studies
We have created a novel series of mushroom tyrosinase inhibitors with 1, 2, 4-triazole as
fundamental skeleton. The target compound 1, 2, 4-triazol-3-ylthio)-N-phenyl acetamide …
fundamental skeleton. The target compound 1, 2, 4-triazol-3-ylthio)-N-phenyl acetamide …
Identification by shape-based virtual screening and evaluation of new tyrosinase inhibitors
Q Li, H Yang, J Mo, Y Chen, Y Wu, C Kang, Y Sun… - PeerJ, 2018 - peerj.com
Targeting tyrosinase is considered to be an effective way to control the production of
melanin. Tyrosinase inhibitor is anticipated to provide new therapy to prevent skin …
melanin. Tyrosinase inhibitor is anticipated to provide new therapy to prevent skin …
Novel 1, 3, 4-oxadiazole compounds inhibit the tyrosinase and melanin level: Synthesis, in-vitro, and in-silico studies
In this research work, we have designed and synthesized some biologically useful of 1, 3, 4-
Oxadiazoles. The structural interpretation of the synthesized compounds has been validated …
Oxadiazoles. The structural interpretation of the synthesized compounds has been validated …
Facile synthesis of new quinazolinone benzamides as potent tyrosinase inhibitors: Comparative spectroscopic and molecular docking studies
The simple reaction approach has been designed and utilized for the synthesis of
quinazolinone benzamides 4a-4h using isatoic anhydride, m-Anisic hydrazide and various …
quinazolinone benzamides 4a-4h using isatoic anhydride, m-Anisic hydrazide and various …
Ultrasound mediated efficient synthesis of new 4-oxoquinazolin-3 (4H)-yl) furan-2-carboxamides as potent tyrosinase inhibitors: Mechanistic approach through …
We have carried out the synthesis of new 4-oxoquinazolin-3 (4H)-yl) furan-2-carboxamide
derivatives by the reaction between isatoic anhydride, 2-furoic hydrazide and substituted …
derivatives by the reaction between isatoic anhydride, 2-furoic hydrazide and substituted …
SAR and QSAR research on tyrosinase inhibitors using machine learning methods
Y Wu, D Huo, G Chen, A Yan - SAR and QSAR in Environmental …, 2021 - Taylor & Francis
Tyrosinase is a key rate-limiting enzyme in the process of melanin synthesis, which is
closely related to human pigmentation disorders. Tyrosinase inhibitors can down-regulate …
closely related to human pigmentation disorders. Tyrosinase inhibitors can down-regulate …