Development of a multicompartment permeability‐limited lung PBPK model and its application in predicting pulmonary pharmacokinetics of antituberculosis drugs

L Gaohua, J Wedagedera, BG Small… - CPT …, 2015 - Wiley Online Library
Achieving sufficient concentrations of antituberculosis (TB) drugs in pulmonary tissue at the
optimum time is still a challenge in developing therapeutic regimens for TB. A …

Clinical use of biomarkers of survival in pulmonary fibrosis

M Thomeer, JC Grutters, WA Wuyts, S Willems… - Respiratory …, 2010 - Springer
Background Biologic predictors or biomarkers of survival in pulmonary fibrosis with a worse
prognosis, more specifically in idiopathic pulmonary fibrosis would help the clinician in …

[PDF][PDF] REVUE SYSTÉMATIQUE

R Kammoun, HB Saad - La Tunisie medicale, 2020 - latunisiemedicale.com
Objectif. The objective of this literature review is to gather all the LFT norms available for the
Tunisian population, as well as QDV questionnaires specific to chronic respiratory patients …

Establishing a hemoglobin adjustment for 129Xe gas exchange MRI and MRS

A Bechtel, J Lu, D Mummy, E Bier… - Magnetic …, 2023 - Wiley Online Library
Purpose 129Xe MRI and MRS signals from airspaces, membrane tissues (M), and red blood
cells (RBCs) provide measurements of pulmonary gas exchange. However, 129Xe …

Airborne particulate matters induce thrombopoiesis from megakaryocytes through regulating mitochondrial oxidative phosphorylation

X Jin, H Yu, B Wang, Z Sun, Z Zhang, QS Liu… - Particle and Fibre …, 2021 - Springer
Background Although airborne fine particulate matter (PM) pollution has been demonstrated
as an independent risk factor for pulmonary and cardiovascular diseases, their currently …

Reference values of pulmonary diffusing capacity for nitric oxide in an adult population

GS Zavorsky, J Cao, JM Murias - Nitric oxide, 2008 - Elsevier
Our objective was to create reference values for single-breath DLNO based on a sample of
non-smoking healthy males and females using a short breath-hold time. The sample …

Diffusing capacity for nitric oxide and carbon monoxide in patients with diffuse parenchymal lung disease and pulmonary arterial hypertension

I van der Lee, P Zanen, JC Grutters, RJ Snijder… - Chest, 2006 - Elsevier
Background The passage of carbon monoxide (CO) through the alveolocapillary membrane
and into the plasma and intraerythrocytic compartments determines the diffusing capacity of …

Sarcoidosis. Disease progression based on radiological and functional course: Predictive factors

A Casal, J Suárez-Antelo, R Soto-Feijóo, L Ferreiro… - Heart & Lung, 2022 - Elsevier
Background Sarcoidosis is a multiorgan granulomatous disease with a variable course.
Oobjectives The purpose of this study is to identify the patients that are more likely to …

Improvement in lung diffusion by endothelin A receptor blockade at high altitude

C De Bisschop, JB Martinot… - Journal of applied …, 2012 - journals.physiology.org
Lung diffusing capacity has been reported variably in high-altitude newcomers and may be
in relation to different pulmonary vascular resistance (PVR). Twenty-two healthy volunteers …

Alveolar-membrane diffusing capacity improves in the morbidly obese after bariatric surgery

GS Zavorsky, DJ Kim, JL Sylvestre, NV Christou - Obesity surgery, 2008 - Springer
Background Morbidly obese individuals may have impaired alveolar-membrane diffusing
capacity (DmCO). The purpose of this study was to measure pulmonary diffusing capacity for …