For more than 25 years, MDM2 and its homolog MDMX (also known as MDM4) have been
shown to exert oncogenic activity. These two proteins are best understood as negative …

The mouse double minute 4 (MDM4) is emerging from the shadow of its more famous
relative MDM2 and is starting to steal the limelight, largely due to its therapeutic possibilities …

Estrogen receptor (ER)-negative tumors represent 20–30% of all breast cancers, with a
higher proportion occurring in younger women and women of African ancestry. The etiology …

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic
variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of …

Two strategies are often adopted for enrichment analysis of pathways: the analysis of all
differentially expressed (DE) genes together or the analysis of up-and downregulated genes …

Overexpression of MDM4 (also known as MDMX or HDMX) is thought to promote
tumorigenesis by decreasing p53 tumor suppressor function. Even modest decrease in …

The ability of p53 to regulate transcription is crucial for tumor suppression and implies that
inherited polymorphisms in functional p53-binding sites could influence cancer. Here, we …

Simple Summary The p53 pathway is a major tumor suppressor pathway that prevents the
propagation of abnormal cells by regulating DNA repair, cell cycle progression, cell death, or …

Exquisite control of the activity of p53 is necessary for mammalian survival. Too much p53 is
lethal, whereas too little permits tumorigenesis. MDM2 and MDM4 are structurally related …

The p53 tumor suppressor pathway is central both in reducing cancer frequency in
vertebrates and in mediating the response of commonly used cancer therapies. This article …