In recent years, because of increased resistance to conventional antimicrobials, many
researchers have started to study the synthesis of new antibiotics to control the disease …

This review covers some of the recent progress in the field of peptide antibiotics with a focus
on compounds with novel or established mode of action and with demonstrated efficacy in …

Proteolytic degradation of peptide-based drugs is often considered as major weakness
limiting systemic therapeutic applications. Therefore, huge efforts are typically devoted to …

With the growing crisis of antimicrobial resistance, it is critical to continue to seek out new
sources of novel antibiotics. This need has led to renewed interest in natural product …

Antibiotic resistance is one of the most challenging global health threats in our society.
Antimicrobial peptides (AMPs) represent promising alternatives to conventional antibiotics …

Antibiotic poly-resistance (multidrug-, extreme-, and pan-drug resistance) is controlled by
adaptive evolution. Darwinian and Lamarckian interpretations of resistance evolution are …

Toward the design of new proline-rich peptidomimetics, a short peptide segment, present in
several proline-rich antimicrobial peptides (AMPs), was selected. Fatty acids of varying …

A long-standing question in infection biology is why two very similar individuals, with very
similar pathogen exposures, may have very different outcomes. Recent experiments have …

Background Cryptococcosis and cryptococcal meningitis, caused by Cryptococcus
neoformans infections, lead to approximately 180,000 deaths per year, primarily in …

Proline-rich antimicrobial peptides (PR-AMPs) having a potent antimicrobial activity
predominantly toward Gram-negative bacteria and negligible toxicity toward host cells, are …