Food safety for food security: Relationship between global megatrends and developments in food safety
Background There is an urgent need to drive improvements in the efficiency and
effectiveness of food chains. The global population is expected to reach at least 9 billion by …
effectiveness of food chains. The global population is expected to reach at least 9 billion by …
Mode of action-based risk assessment of genotoxic carcinogens
A Hartwig, M Arand, B Epe, S Guth, G Jahnke… - Archives of …, 2020 - Springer
The risk assessment of chemical carcinogens is one major task in toxicology. Even though
exposure has been mitigated effectively during the last decades, low levels of carcinogenic …
exposure has been mitigated effectively during the last decades, low levels of carcinogenic …
p53 triggers mitochondrial apoptosis following DNA damage-dependent replication stress by the hepatotoxin methyleugenol
MJ Carlsson, AS Vollmer, P Demuth, D Heylmann… - Cell Death & …, 2022 - nature.com
Liver cancer is one of the most frequent tumor entities worldwide, which is causally linked to
viral infection, fatty liver disease, life-style factors and food-borne carcinogens, particularly …
viral infection, fatty liver disease, life-style factors and food-borne carcinogens, particularly …
The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment
IMCM Rietjens, A Michael, HM Bolt, B Siméon… - Archives of …, 2022 - Springer
The “totality” of the human exposure is conceived to encompass life-associated endogenous
and exogenous aggregate exposures. Process-related contaminants (PRCs) are not only …
and exogenous aggregate exposures. Process-related contaminants (PRCs) are not only …
Mass spectrometry for the assessment of the occurrence and biological consequences of DNA adducts
Exogenous and endogenous sources of chemical species can react, directly or after
metabolic activation, with DNA to yield DNA adducts. If not repaired, DNA adducts may …
metabolic activation, with DNA to yield DNA adducts. If not repaired, DNA adducts may …
DNA damage resulting from human endocrine disrupting chemical exposure: Genotoxicity, detection and dietary phytochemical intervention
X Li, N Zang, N Zhang, L Pang, L Lv, X Meng, X Lv… - Chemosphere, 2023 - Elsevier
In recent years, exposure to endocrine disrupting chemicals (EDCs) has posed an
increasing threat to human health. EDCs are major risk factors in the occurrence and …
increasing threat to human health. EDCs are major risk factors in the occurrence and …
Recent studies on DNA adducts resulting from human exposure to tobacco smoke
B Ma, I Stepanov, SS Hecht - Toxics, 2019 - mdpi.com
DNA adducts are believed to play a central role in the induction of cancer in cigarette
smokers and are proposed as being potential biomarkers of cancer risk. We have …
smokers and are proposed as being potential biomarkers of cancer risk. We have …
The multifarious link between cytochrome P450s and cancer
AM Alzahrani, P Rajendran - Oxidative Medicine and Cellular …, 2020 - Wiley Online Library
Cancer is a leading cause of death worldwide. Cytochrome P450s (P450s) play an
important role in the metabolism of endogenous as well as exogenous substances …
important role in the metabolism of endogenous as well as exogenous substances …
Genotoxic and epigenotoxic effects in mice exposed to concentrated ambient fine particulate matter (PM2.5) from São Paulo city, Brazil
AAF de Oliveira, TF de Oliveira, MF Dias… - Particle and fibre …, 2018 - Springer
Abstract Background The Metropolitan Area of São Paulo has a unique composition of
atmospheric pollutants, and positive correlations between exposure and the risk of diseases …
atmospheric pollutants, and positive correlations between exposure and the risk of diseases …
Alkenylbenzenes in foods: Aspects impeding the evaluation of adverse health effects
A Eisenreich, ME Götz, B Sachse, BH Monien… - Foods, 2021 - mdpi.com
Alkenylbenzenes are naturally occurring secondary plant metabolites, primarily present in
different herbs and spices, such as basil or fennel seeds. Thus, alkenylbenzenes, such as …
different herbs and spices, such as basil or fennel seeds. Thus, alkenylbenzenes, such as …