Food safety for food security: Relationship between global megatrends and developments in food safety

T King, M Cole, JM Farber, G Eisenbrand… - Trends in Food Science …, 2017 - Elsevier
Background There is an urgent need to drive improvements in the efficiency and
effectiveness of food chains. The global population is expected to reach at least 9 billion by …

Mode of action-based risk assessment of genotoxic carcinogens

A Hartwig, M Arand, B Epe, S Guth, G Jahnke… - Archives of …, 2020 - Springer
The risk assessment of chemical carcinogens is one major task in toxicology. Even though
exposure has been mitigated effectively during the last decades, low levels of carcinogenic …

p53 triggers mitochondrial apoptosis following DNA damage-dependent replication stress by the hepatotoxin methyleugenol

MJ Carlsson, AS Vollmer, P Demuth, D Heylmann… - Cell Death & …, 2022 - nature.com
Liver cancer is one of the most frequent tumor entities worldwide, which is causally linked to
viral infection, fatty liver disease, life-style factors and food-borne carcinogens, particularly …

The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment

IMCM Rietjens, A Michael, HM Bolt, B Siméon… - Archives of …, 2022 - Springer
The “totality” of the human exposure is conceived to encompass life-associated endogenous
and exogenous aggregate exposures. Process-related contaminants (PRCs) are not only …

Mass spectrometry for the assessment of the occurrence and biological consequences of DNA adducts

S Liu, Y Wang - Chemical Society Reviews, 2015 - pubs.rsc.org
Exogenous and endogenous sources of chemical species can react, directly or after
metabolic activation, with DNA to yield DNA adducts. If not repaired, DNA adducts may …

DNA damage resulting from human endocrine disrupting chemical exposure: Genotoxicity, detection and dietary phytochemical intervention

X Li, N Zang, N Zhang, L Pang, L Lv, X Meng, X Lv… - Chemosphere, 2023 - Elsevier
In recent years, exposure to endocrine disrupting chemicals (EDCs) has posed an
increasing threat to human health. EDCs are major risk factors in the occurrence and …

Recent studies on DNA adducts resulting from human exposure to tobacco smoke

B Ma, I Stepanov, SS Hecht - Toxics, 2019 - mdpi.com
DNA adducts are believed to play a central role in the induction of cancer in cigarette
smokers and are proposed as being potential biomarkers of cancer risk. We have …

The multifarious link between cytochrome P450s and cancer

AM Alzahrani, P Rajendran - Oxidative Medicine and Cellular …, 2020 - Wiley Online Library
Cancer is a leading cause of death worldwide. Cytochrome P450s (P450s) play an
important role in the metabolism of endogenous as well as exogenous substances …

Genotoxic and epigenotoxic effects in mice exposed to concentrated ambient fine particulate matter (PM2.5) from São Paulo city, Brazil

AAF de Oliveira, TF de Oliveira, MF Dias… - Particle and fibre …, 2018 - Springer
Abstract Background The Metropolitan Area of São Paulo has a unique composition of
atmospheric pollutants, and positive correlations between exposure and the risk of diseases …

Alkenylbenzenes in foods: Aspects impeding the evaluation of adverse health effects

A Eisenreich, ME Götz, B Sachse, BH Monien… - Foods, 2021 - mdpi.com
Alkenylbenzenes are naturally occurring secondary plant metabolites, primarily present in
different herbs and spices, such as basil or fennel seeds. Thus, alkenylbenzenes, such as …