Caspase-3 is a widely expressed member of a conserved family of proteins, generally
recognized for their activated proteolytic roles in the execution of apoptosis in cells …

Executioner caspases, when activated, cleave hundreds or thousands of substrates in the
cell to orchestrate apoptosis. In most animals, the executioner caspases have short …

All life ends in death, but perhaps one of life's grander ironies is that it also depends on
death. Cell-intrinsic suicide pathways, termed programmed cell death (PCD), are crucial for …

The mitochondria-mediated caspase activation pathway is a major apoptotic pathway
characterized by mitochondrial outer membrane permeabilization (MOMP) and subsequent …

The realization that alterations in inhibitor of apoptosis (IAP) proteins are found in many
types of human cancer and are associated with chemoresistance, disease progression and …

The initial insight into the genetic basis of apoptosis, or programmed cell death, was gained
from ingenious studies of the roundworm Caenorhabditis elegans (for review, see Horvitz …

Caspases, which are the executioners of apoptosis, comprise two distinct classes, the
initiators and the effectors. Although general structural features are shared between the …

Caspases are central components of the machinery responsible for apoptosis. Recent
structural and biochemical studies on procaspases, IAPs, Smac/DIABLO, and apoptosome …

To identify proteins that bind mammalian IAP homolog A (MIHA, also known as XIAP), we
used coimmunoprecipitation and 2D immobilized pH gradient/SDS PAGE, followed by …

Programmed cell death plays critical roles in a wide variety of physiological processes
during fetal development and in adult tissues. In most cases, physiological cell death occurs …