Next-generation flexible formats of VNAR domains expand the drug platform's utility and developability
OC Ubah, MJ Buschhaus, L Ferguson… - Biochemical Society …, 2018 - portlandpress.com
Therapeutic mAbs have delivered several blockbuster drugs in oncology and autoimmune
inflammatory disease. Revenue for mAbs continues to rise, even in the face of competition …
inflammatory disease. Revenue for mAbs continues to rise, even in the face of competition …
Synthetic libraries of shark vNAR domains with different cysteine numbers within the CDR3
O Cabanillas-Bernal, S Dueñas, M Ayala-Avila… - PLoS …, 2019 - journals.plos.org
The variable domain of New Antigen Receptors (vNAR) from sharks, present special
characteristics in comparison to the conventional antibody molecules such as: small size (12 …
characteristics in comparison to the conventional antibody molecules such as: small size (12 …
Chimeric Peptides from Californiconus californicus and Heterodontus francisci with Antigen-Binding Capacity: A Conotoxin Scaffold to Create Non-Natural …
S Dueñas, T Escalante, J Gasperin-Bulbarela… - Toxins, 2023 - mdpi.com
Research into various proteins capable of blocking metabolic pathways has improved the
detection and treatment of multiple pathologies associated with the malfunction and …
detection and treatment of multiple pathologies associated with the malfunction and …
Preparation of immune and synthetic VNAR libraries as sources of high-affinity binders
J Gasperin-Bulbarela, O Cabanillas-Bernal… - … Antibodies: Methods and …, 2022 - Springer
The shark-derived autonomous variable antibody domains known as VNARs are attractive
tools for therapeutic and diagnostic applications due to their favorable properties like small …
tools for therapeutic and diagnostic applications due to their favorable properties like small …
Evaluación de la capacidad neutralizante de TNFα por una proteína quimérica diseñada in silico a partir de un VNAR
MR Maciel - 2021 - cicese.repositorioinstitucional.mx
Los tratamientos anti-TNFα actuales presentan variados efectos secundarios y en algunos
casos resultan ineficientes ya que se desarrolla tolerancia. En la búsqueda de tratamientos …
casos resultan ineficientes ya que se desarrolla tolerancia. En la búsqueda de tratamientos …
Novel CD123 Binders for CAR-T Cell Therapy
F Parekh - 2020 - discovery.ucl.ac.uk
CD123-the a-chain of the IL-3 cytokine receptor (IL3RA)-is a promising new
immunotherapeutic target due to its surface expression on a multitude of leukemic disorders …
immunotherapeutic target due to its surface expression on a multitude of leukemic disorders …
Generación y caracterización de tres bibliotecas sintéticas de anticuerpos basadas en tres marcos de anticuerpos vNAR
OC BERNAL - 2019 - cicese.repositorioinstitucional.mx
Los fragmentos de anticuerpos de dominio sencillo vNAR, derivados de tiburones,
presentan características especiales en comparación con las moléculas convencionales de …
presentan características especiales en comparación con las moléculas convencionales de …