Transduction of receptor signals by β-arrestins
RJ Lefkowitz, SK Shenoy - science, 2005 - science.org
The transmission of extracellular signals to the interior of the cell is a function of plasma
membrane receptors, of which the seven transmembrane receptor family is by far the largest …
membrane receptors, of which the seven transmembrane receptor family is by far the largest …
Insulin-like growth factor-I receptor and thyroid-associated ophthalmopathy
TJ Smith, JA Janssen - Endocrine Reviews, 2019 - academic.oup.com
Thyroid-associated ophthalmopathy (TAO) is a complex disease process presumed to
emerge from autoimmunity occurring in the thyroid gland, most frequently in Graves disease …
emerge from autoimmunity occurring in the thyroid gland, most frequently in Graves disease …
[HTML][HTML] β-Arrestin–dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2
Recently, a requirement for β-arrestin–mediated endocytosis in the activation of extracellular
signal–regulated kinases 1 and 2 (ERK1/2) by several G protein–coupled receptors …
signal–regulated kinases 1 and 2 (ERK1/2) by several G protein–coupled receptors …
Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors
CE Stewart, P Rotwein - Physiological reviews, 1996 - journals.physiology.org
The insulin-like growth factors (IGFs), IGF-I and IGF-II, comprise a conserved pair of secreted
proteins with diverse effects on growth, development, and metabolism. Insulin-like growth …
proteins with diverse effects on growth, development, and metabolism. Insulin-like growth …
Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex.
Neocortical neuroblast cell lines were used to clone G-protein-coupled receptor (GPCR)
genes to study signaling mechanisms regulating cortical neurogenesis. One putative GPCR …
genes to study signaling mechanisms regulating cortical neurogenesis. One putative GPCR …
Beyond desensitization: physiological relevance of arrestin-dependent signaling
LM Luttrell, D Gesty-Palmer - Pharmacological reviews, 2010 - ASPET
Heptahelical G protein-coupled receptors are the most diverse and therapeutically important
family of receptors in the human genome. Ligand binding activates heterotrimeric G proteins …
family of receptors in the human genome. Ligand binding activates heterotrimeric G proteins …
β-Arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
M Azzi, PG Charest, S Angers… - Proceedings of the …, 2003 - National Acad Sciences
It is becoming increasingly clear that signaling via G protein-coupled receptors is a diverse
phenomenon involving receptor interaction with a variety of signaling partners. Despite this …
phenomenon involving receptor interaction with a variety of signaling partners. Despite this …
New insights into IGF-1 signaling in the heart
Insulin-like growth factor 1 (IGF-1) signaling regulates contractility, metabolism, hypertrophy,
autophagy, senescence, and apoptosis in the heart. IGF-1 deficiency is associated with an …
autophagy, senescence, and apoptosis in the heart. IGF-1 deficiency is associated with an …
Sphingosine 1-phosphate signalling in mammalian cells
Sphingosine 1-phosphate is formed in cells in response to diverse stimuli, including growth
factors, cytokines, G-protein-coupled receptor agonists, antigen, etc. Its production is …
factors, cytokines, G-protein-coupled receptor agonists, antigen, etc. Its production is …
Evidence for an association between thyroid-stimulating hormone and insulin-like growth factor 1 receptors: a tale of two antigens implicated in Graves' disease
S Tsui, V Naik, N Hoa, CJ Hwang… - The Journal of …, 2008 - journals.aai.org
Thyroid-stimulating hormone receptor (TSHR) plays a central role in regulating thyroid
function and is targeted by IgGs in Graves' disease (GD-IgG). Whether TSHR is involved in …
function and is targeted by IgGs in Graves' disease (GD-IgG). Whether TSHR is involved in …