Drug repurposing in cancer
L Sleire, HE Førde, IA Netland, L Leiss, BS Skeie… - Pharmacological …, 2017 - Elsevier
Cancer is a major health issue worldwide, and the global burden of cancer is expected to
increase in the coming years. Whereas the limited success with current therapies has driven …
increase in the coming years. Whereas the limited success with current therapies has driven …
[HTML][HTML] ONC201 and imipridones: Anti-cancer compounds with clinical efficacy
ONC201 was originally discovered as TNF-Related Apoptosis Inducing Ligand (TRAIL)-
inducing compound TIC10. ONC201 appears to act as a selective antagonist of the G …
inducing compound TIC10. ONC201 appears to act as a selective antagonist of the G …
[HTML][HTML] Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care
M De Hert, CU Correll, J Bobes… - World …, 2011 - ncbi.nlm.nih.gov
The lifespan of people with severe mental illness (SMI) is shorter compared to the general
population. This excess mortality is mainly due to physical illness. We report prevalence …
population. This excess mortality is mainly due to physical illness. We report prevalence …
Patterns of tobacco-related mortality among individuals diagnosed with schizophrenia, bipolar disorder, or depression
RC Callaghan, S Veldhuizen, T Jeysingh… - Journal of psychiatric …, 2014 - Elsevier
Even though individuals with psychiatric conditions have a prevalence of smoking
approximately 2–4 times greater than the general population, surprisingly little evidence …
approximately 2–4 times greater than the general population, surprisingly little evidence …
Combining electronic healthcare databases in Europe to allow for large‐scale drug safety monitoring: the EU‐ADR Project
Purpose In this proof‐of‐concept paper we describe the framework, process, and
preliminary results of combining data from European electronic healthcare record (EHR) …
preliminary results of combining data from European electronic healthcare record (EHR) …
Repurposing of antipsychotic trifluoperazine for treating brain metastasis, lung metastasis and bone metastasis of melanoma by disrupting autophagy flux
Y Xia, F Xu, M Xiong, H Yang, W Lin, Y Xie, H Xi… - Pharmacological …, 2021 - Elsevier
Targeted therapies and immunotherapy have brought substantial benefits to patients with
melanoma. However, brain metastases remain the biggest threat to the survival and quality …
melanoma. However, brain metastases remain the biggest threat to the survival and quality …
Cancer incidence in patients with schizophrenia and their first‐degree relatives–a meta‐analysis
VS Catts, SV Catts, BI O'toole… - Acta Psychiatrica …, 2008 - Wiley Online Library
Objective: Controversy concerning cancer incidence in schizophrenia exists because of
heterogeneous study findings. Method: A meta‐analysis was performed on standardized …
heterogeneous study findings. Method: A meta‐analysis was performed on standardized …
Secondary effects of antipsychotics: women at greater risk than men
MV Seeman - Schizophrenia bulletin, 2009 - academic.oup.com
Context: The health burden of antipsychotic medication is well known, but the
disproportionate effect on women as compared with men is underappreciated. Objective …
disproportionate effect on women as compared with men is underappreciated. Objective …
The incidence and relative risk factors for developing cancer among patients with schizophrenia: a nine-year follow-up study
FHC Chou, KY Tsai, CY Su, CC Lee - Schizophrenia research, 2011 - Elsevier
OBJECTIVE: To estimate the incidence and relative risk of developing cancer as well as the
mortality rate after cancer diagnosis for patients with schizophrenia compared with the …
mortality rate after cancer diagnosis for patients with schizophrenia compared with the …
Trifluoperazine, a Well-Known Antipsychotic, Inhibits Glioblastoma Invasion by Binding to Calmodulin and Disinhibiting Calcium Release Channel IP3R
Abstract Calcium (Ca2+) signaling is an important signaling process, implicated in cancer
cell proliferation and motility of the deadly glioblastomas that aggressively invade …
cell proliferation and motility of the deadly glioblastomas that aggressively invade …