Abstract Type I Interferons (IFN-I) mediate numerous immune interactions during viral
infections, from the establishment of an antiviral state to invoking and regulating innate and …

Human immunodeficiency virus type 1 (HIV-1) is the causative agent of acquired
immunodeficiency syndrome and its infection leads to the onset of several disorders such as …

Summary Guanylate-binding protein (GBP) 5 is an interferon (IFN)-inducible cellular factor
reducing HIV-1 infectivity by an incompletely understood mechanism. Here, we show that …

The direct link between sustained type I interferon (IFN-I) signaling and HIV-1–induced
immunopathogenesis during chronic infection remains unclear. Here we report studies …

Human immunodeficiency virus (HIV) remains a significant source of morbidity and mortality
worldwide. No effective vaccine is available to prevent HIV transmission, and although …

Type I interferons (IFNs) are critical effector cytokines of the immune system and were
originally known for their important role in protecting against viral infections; however, they …

Chronic activation of the immune system in HIV infection is one of the strongest predictors of
morbidity and mortality. As such, approaches that reduce immune activation have received …

Summary Cyclic GMP-AMP synthase (cGAS) recognizes Y-form cDNA of human
immunodeficiency virus type 1 (HIV-1) and initiates antiviral immune response through …

The Type I Interferons (IFN-Is) are innate antiviral cytokines that include 12 different IFNα
subtypes and IFNβ that signal through the IFN-I receptor (IFNAR), inducing hundreds of IFN …

Type I interferon (IFN) response initially limits HIV-1 spread and may delay disease
progression by stimulating several immune system components. Nonetheless, persistent …