Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses

LN Vandenberg, T Colborn, TB Hayes… - Endocrine …, 2012 - academic.oup.com
For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional
concepts in toxicology, in particular the dogma of “the dose makes the poison,” because …

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

WH Goodson III, L Lowe, DO Carpenter… - …, 2015 - academic.oup.com
Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide,
but credible estimates from the World Health Organization and the International Agency for …

Fungicides: an overlooked pesticide class?

JP Zubrod, M Bundschuh, G Arts… - … science & technology, 2019 - ACS Publications
Fungicides are indispensable to global food security and their use is forecasted to intensify.
Fungicides can reach aquatic ecosystems and occur in surface water bodies in agricultural …

[HTML][HTML] A critical review of synthetic chemicals in surface waters of the US, the EU and China

W Fang, Y Peng, D Muir, J Lin, X Zhang - Environment international, 2019 - Elsevier
There is a wide concern that emerging organic pollutants (EOPs) in surface water could
adversely affect human health and wildlife. However, the geographic distribution, exposure …

[图书][B] Fundamentals of ecotoxicology

MC Newman - 2009 - taylorfrancis.com
Each year ecotoxicological problems become increasingly complex and encompass
broader spatial and temporal scales. Our practical understanding must evolve accordingly to …

Nonmonotonic dose–response curves occur in dose ranges that are relevant to regulatory decision-making

CE Hill, JP Myers, LN Vandenberg - Dose-Response, 2018 - journals.sagepub.com
Non-monotonic dose response curves (NMDRCs) occur in cells, tissues, animals and
human populations in response to nutrients, vitamins, pharmacological compounds …

The pros and cons of ecological risk assessment based on data from different levels of biological organization

JR Rohr, CJ Salice, RM Nisbet - Critical Reviews in Toxicology, 2016 - Taylor & Francis
Ecological risk assessment (ERA) is the process used to evaluate the safety of manufactured
chemicals to the environment. Here we review the pros and cons of ERA across levels of …

Fungicide‐induced declines of freshwater biodiversity modify ecosystem functions and services

TA McMahon, NT Halstead, S Johnson… - Ecology …, 2012 - Wiley Online Library
Although studies on biodiversity and ecosystem function are often framed within the context
of anthropogenic change, a central question that remains is how important are direct vs …

Repeated exposure to fungicide tebuconazole alters the degradation characteristics, soil microbial community and functional profiles

L Han, X Kong, M Xu, J Nie - Environmental Pollution, 2021 - Elsevier
Tebuconazole is a broad-spectrum triazole fungicide that has been extensively applied in
agriculture, but its toxicity on soil ecology remains unknown after repeated introduction to …

A synthesis of the effects of pesticides on microbial persistence in aquatic ecosystems

ZR Staley, VJ Harwood, JR Rohr - Critical reviews in toxicology, 2015 - Taylor & Francis
Pesticides have a pervasive presence in aquatic ecosystems throughout the world. While
pesticides are intended to control fungi, insects, and other pests, their mechanisms of action …