Mechanism and biological role of Dnmt2 in nucleic acid methylation

A Jeltsch, A Ehrenhofer-Murray, TP Jurkowski… - RNA biology, 2017 - Taylor & Francis
ABSTRACT A group of homologous nucleic acid modification enzymes called Dnmt2,
Trdmt1, Pmt1, DnmA, and Ehmet in different model organisms catalyze the transfer of a …

[HTML][HTML] The emerging field of epitranscriptomics in neurodevelopmental and neuronal disorders

MT Angelova, DG Dimitrova, N Dinges… - … in bioengineering and …, 2018 - frontiersin.org
Analogous to DNA methylation and histone modifications, RNA modifications represent a
novel layer of regulation of gene expression. The dynamic nature and increasing number of …

RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage

M Schaefer, T Pollex, K Hanna, F Tuorto… - Genes & …, 2010 - genesdev.cshlp.org
Dnmt2 proteins are the most conserved members of the DNA methyltransferase enzyme
family, but their substrate specificity and biological functions have been a subject of …

Solving the Dnmt2 enigma

M Schaefer, F Lyko - Chromosoma, 2010 - Springer
Dnmt2 is a member of the animal DNA methyltransferase family of enzymes. While the role
of other Dnmt proteins has been extensively characterized, comparably little is known about …

Characterization of the dual role of Plasmodium falciparum DNA methyltransferase in regulating transcription and translation

AB Lucky, C Wang, X Li, A Chim-Ong… - Nucleic acids …, 2023 - academic.oup.com
DNA modifications are critical in fine-tuning the biological processes in model organisms.
However, the presence of cytosine methylation (5mC) and the function of the putative DNA …

[HTML][HTML] Prolonged effects of silver nanoparticles on p53/p21 pathway-mediated proliferation, DNA damage response, and methylation parameters in HT22 …

J Mytych, J Zebrowski, A Lewinska, M Wnuk - Molecular neurobiology, 2017 - Springer
It is widely accepted that silver nanoparticles (AgNPs) are toxic to biological systems.
However, little is known about their actions at molecular level and the cytophysiological …

[HTML][HTML] TRDMT1-mediated RNA C-5 methylation as a novel target in anticancer therapy

A Lewinska, J Adamczyk-Grochala, M Wnuk - Biochimica et Biophysica …, 2023 - Elsevier
Affected landscape of RNA modifications is frequently observed in different cancer cells that
can be associated with the development of cancer cell phenotypic traits such as sustained …

Mapping and significance of the mRNA methylome

T Sibbritt, HR Patel, T Preiss - Wiley Interdisciplinary Reviews …, 2013 - Wiley Online Library
Internal methylation of eukaryotic mRNAs in the form of N6‐methyladenosine (m6A) and 5‐
methylcytidine (m5C) has long been known to exist, but progress in understanding its role …

[HTML][HTML] Reduced levels of methyltransferase DNMT2 sensitize human fibroblasts to oxidative stress and DNA damage that is accompanied by changes in proliferation …

A Lewinska, J Adamczyk-Grochala, E Kwasniewicz… - Redox Biology, 2018 - Elsevier
Methyltransferase DNMT2 is suggested to be involved in the regulation of numerous
processes, however its biological significance and underlying molecular mechanisms …

TRDMT1 exhibited protective effects against LPS‐induced inflammation in rats through TLR4‐NF‐κB/MAPK‐TNF‐α pathway

Z Li, X Qi, X Zhang, L Yu, L Gao, W Kong… - Animal Models and …, 2022 - Wiley Online Library
Background Inflammation is a complex physiological and pathological process. Although
many types of inflammation are well characterized, their physiological functions are largely …