Lactylation is a process where lactate, a cellular metabolism byproduct, is added to proteins,
altering their functions. In the realm of macrophage activation, lactylation impacts …

Cardiometabolic diseases (CMDs) denote a cadre of chronic and devastating
cardiovascular anomalies routed from metabolic derangements including obesity, type 2 …

Objectives We have previously shown that lactate is an essential metabolite for macrophage
polarisation during ischemia-induced muscle regeneration. Recent in vitro work has …

Dynamic alterations in cellular phenotypes during cancer progression are attributed to a
phenomenon known as 'lineage plasticity'. This process is associated with therapeutic …

Histone lysine lactylation (Kla) has emerged as a distinct epigenetic modification that differs
markedly from established acylation modifications through the unique addition of a lactyl …

Highlights•Spatial metabolomics technology has made great advancements in recent
years.•Metabolic molecular histology is a powerful tool to reveal cellular states.•Dynamic …

Background Previous studies have shown that the vitrification of metaphase II (MII) oocytes
significantly represses their developmental potential. Abnormally increased oxidative stress …

Lactate, a metabolic byproduct, has gained recognition as a highly influential signaling
molecule. Lactylation, an emerging form of post-translational modification derived from …

The intersection of metabolic processes and epigenetic regulation during embryogenesis is
crucial yet not fully understood. Through a candidate RNAi screen in Caenorhabditis …

In mammals, the neonatal heart can regenerate upon injury within a short time after birth,
while adults lose this ability. Metabolic reprogramming has been demonstrated to be critical …