Mechanobiology emerges at the crossroads of medicine, biology, biophysics and
engineering and describes how the responses of proteins, cells, tissues and organs to …

Physical forces and mechanical properties have critical roles in cellular function, physiology
and disease. Over the past decade, atomic force microscopy (AFM) techniques have …

During the last three decades, a series of key technological improvements turned atomic
force microscopy (AFM) into a nanoscopic laboratory to directly observe and chemically …

Mechanical properties play important roles at different scales in biology. At the level of a
single cell, the mechanical properties mediate mechanosensing and mechanotransduction …

Cell migration through 3D tissue depends on a physicochemical balance between cell
deformability and physical tissue constraints. Migration rates are further governed by the …

We present a procedure that allows a reliable determination of the elastic (Young's) modulus
of soft samples, including living cells, by atomic force microscopy (AFM). The standardized …

for a rectangular cantilever requires measurement of the resonant frequency and quality
factor in fluid (typically air), and knowledge of its plan view dimensions. This intrinsically …

The multistep process of cell migration requires cells to dynamically couple to extracellular
interfaces and generate traction force or friction for displacement of the cell body. When …

Unraveling the mechanisms that govern the formation and function of invadopodia is
essential towards the prevention of cancer spread. Here, we characterize the ultrastructural …

Sensing force is crucial to maintain the viability of all living cells. Despite its fundamental
importance, how force is sensed at the molecular level remains largely unknown. Here we …