Synthetic Biology offers qualitatively new perspectives on the benefits of industrially
harnessed biological processes. The ability to modify and reprogramme natural biology …

The interdisciplinary field of systems biology has evolved rapidly over the last years.
Different disciplines have aided the development of both its experimental and theoretical …

Physicochemical models of signaling pathways are characterized by high levels of structural
and parametric uncertainty, reflecting both incomplete knowledge about signal transduction …

The epidermal growth factor receptor (EGFR) signaling pathway is probably the best-studied
receptor system in mammalian cells, and it also has become a popular example for …

Persistence is the property, for differential equations in Rn, that solutions starting in the
positive orthant do not approach the boundary of the orthant. For chemical reactions and …

Like engineering systems, biological systems must also operate effectively in the presence
of internal and external uncertainty—such as genetic mutations or temperature changes, for …

Mass-action chemical reaction systems are frequently used in computational biology. The
corresponding polynomial dynamical systems are often large (consisting of tens or even …

The multisite phosphorylation-dephosphorylation cycle is a motif repeatedly used in cell
signaling. This motif itself can generate a variety of dynamic behaviors like bistability and …

In analyzing and mathematical modeling of complex (bio) chemical reaction networks,
formal methods that connect network structure and dynamic behavior are needed because …

Dual phosphorylation of proteins is a principal component of intracellular signalling.
Bistability is considered an important property of such systems and its origin is not yet …