Macrophage polarization and its role in liver disease

C Wang, C Ma, L Gong, Y Guo, K Fu, Y Zhang… - Frontiers in …, 2021 - frontiersin.org
Macrophages are important immune cells in innate immunity, and have remarkable
heterogeneity and polarization. Under pathological conditions, in addition to the resident …

Biodegradable calcium phosphate nanoparticles for cancer therapy

R Khalifehzadeh, H Arami - Advances in colloid and interface science, 2020 - Elsevier
Calcium phosphate is the inorganic mineral of hard tissues such as bone and teeth. Due to
their similarities to the natural bone, calcium phosphates are highly biocompatible and …

Nanocatalytic theranostics with glutathione depletion and enhanced reactive oxygen species generation for efficient cancer therapy

LH Fu, Y Wan, C Qi, J He, C Li, C Yang, H Xu… - Advanced …, 2021 - Wiley Online Library
Chemodynamic therapy (CDT) is an emerging therapy method that kills cancer cells by
converting intracellular hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals (• OH) …

Biodegradable manganese-doped calcium phosphate nanotheranostics for traceable cascade reaction-enhanced anti-tumor therapy

LH Fu, YR Hu, C Qi, T He, S Jiang, C Jiang, J He, J Qu… - Acs Nano, 2019 - ACS Publications
Glucose oxidase (GOx) has been recognized as a “star” enzyme catalyst involved in cancer
treatment in the past few years. Herein, GOx is mineralized with manganese-doped calcium …

Biodegradable calcium phosphate nanotheranostics with tumor‐specific activatable cascade catalytic reactions‐augmented photodynamic therapy

LH Fu, Y Wan, C Li, C Qi, T He, C Yang… - Advanced Functional …, 2021 - Wiley Online Library
Photodynamic therapy (PDT) is exploited as a promising strategy for cancer treatment.
However, the hypoxic solid tumor and the lack of tumor‐specific photosensitizer …

Mesenchymal stem cell-derived exosomes protect against liver fibrosis via delivering miR-148a to target KLF6/STAT3 pathway in macrophages

S Tian, X Zhou, M Zhang, L Cui, B Li, Y Liu… - Stem cell research & …, 2022 - Springer
Background Despite emerging evidence on the therapeutic potential of mesenchymal stem
cells (MSCs) for liver fibrosis, the underlying mechanisms remain unclear. At present, MSC …

Acidity-responsive cascade nanoreactor based on metal-nanozyme and glucose oxidase combination for starving and photothermal-enhanced chemodynamic …

T Wang, D Dong, T Chen, J Zhu, S Wang… - Chemical Engineering …, 2022 - Elsevier
Persistent inflammation and bacterial infection are common during wound healing, and high
blood sugar provides enough nutrients for bacterial growth to make wounds more prone to …

Glucose oxidase‐instructed biomineralization of calcium‐based biomaterials for biomedical applications

LH Fu, C Qi, T Sun, K Huang, J Lin, P Huang - Exploration, 2023 - Wiley Online Library
In recent years, glucose oxidase (GOx) has aroused great research interest in the treatment
of diseases related to abnormal glucose metabolisms like cancer and diabetes. However, as …

Liver fibrosis resolution: from molecular mechanisms to therapeutic opportunities

Q Pei, Q Yi, L Tang - International Journal of Molecular Sciences, 2023 - mdpi.com
The liver is a critical system for metabolism in human beings, which plays an essential role
in an abundance of physiological processes and is vulnerable to endogenous or exogenous …

3D printed enzyme‐functionalized scaffold facilitates diabetic bone regeneration

C Yang, Z Zheng, MR Younis, C Dong… - Advanced Functional …, 2021 - Wiley Online Library
Patients with diabetes mellitus (DM) suffer from a high risk of fractures and poor bone
healing ability. Surprisingly, no effective therapy is available to treat diabetic bone defect in …